Quartz-based photonic crystal surfaces for multiplexed cancer biomarker detection

Cheng-Sheng Huang, V. Chaudhery, J. Polans, M. Lu, B. T. Cunningham*, A. Pokhriyal, S. George, R. C. Zangar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


We report for the first time the combination of a quartz-based photonic crystal (PC) with a detection instrument designed to perform label-free (LF) and enhanced fluorescence (EF) imaging for antibody microarray applications. Label-free detection is used to quantify binding density of immobilized capture antibodies. Angle-scanning approach is implemented to achieve more uniform fluorescence enhancement by reducing the coefficient of variation of replicate assays by 20-99% compared to ordinary fluorescence microscopy.

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
StatePublished - 2012
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan
Duration: 28 Oct 201231 Oct 2012

Publication series

NameProceedings of IEEE Sensors


Conference11th IEEE SENSORS 2012 Conference


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