Quantitative flow measurement by digital subtraction angiography in cerebral carotid stenosis using optical flow method

Tzung Chi Huang, Tung Hsin Wu, Yang Hsien Lin, Wan Yuo Guo, Wei Chien Huang, Chung Jung Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

OBJECTIVE: We analyzed intracranial regional blood flows using an optical flow method (OFM) and digital subtraction angiography in patients with internal carotid artery (ICA) stenosis. We also retrospectively explored the correlation between the patients' diagnoses and the severity of the ICA stenoses. MATERIALS AND METHODS: OFM, an image-processing algorithm to estimate motion, was applied to determine the mean velocity Vmean in the vessels. A group of 40 patients without vascular anomalies acted as the control group. The patients were classified as having either moderate stenosis (< 80%, n=14) or severe stenosis (> 80%, n=23). RESULTS: The Vmean of the ICAs was significantly lower in the stenotic group compared with the control group (p< 0.01). The Vmean of the ICAs was inversely correlated with the severity of the stenosis (p< 0.05). The receiver operating characteristic curve of the Vmean in an AP view showed substantial discriminatory power, with an optimal cutoff value of 3.48 pixels/frame for the detection of patients with carotid stenosis. The sensitivity and specificity were 84% and 50%, respectively. On a lateral view, the best cutoff for the Vmean was 4.01 pixels/frame, and the sensitivity and specificity were 92% and 43%, respectively. CONCLUSIONS: Digital subtraction angiography combined with the OFM is a feasible parametric method for intracranial blood flow measurements in patients with moderate to severe carotid stenosis.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalJournal of X-Ray Science and Technology
Volume21
Issue number2
DOIs
StatePublished - 2013

Keywords

  • Stenosis
  • blood flow
  • optical flow method

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