Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography

Jia Pu Syu, Min Jyun Su, Po Wei Chen, Chang Chih Ke, Shih Hwa Chiou*, Wen Chuan Kuo

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS rats (55 weeks), the thickness of photoreceptor layer decreased significantly as compared to young RCS rats (both 4 weeks and 5 weeks). After contrast enhancement method, this platform will be useful for the quantitative evaluation of the degree of retinal degeneration, treatment outcome after therapy, and drug screening development in the future.

Original languageEnglish
Title of host publicationOphthalmic Technologies XXVIII
EditorsArthur Ho, Per G. Soderberg, Fabrice Manns
PublisherSPIE
ISBN (Electronic)9781510614338
DOIs
StatePublished - 2018
Event28th Conference on Ophthalmic Technologies - San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10474
ISSN (Print)1605-7422

Conference

Conference28th Conference on Ophthalmic Technologies
Country/TerritoryUnited States
CitySan Francisco
Period27/01/1828/01/18

Keywords

  • retinal degeneration
  • Royal College of Surgeons rat
  • spectral domain optical coherence tomography

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