TY - JOUR
T1 - Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography
AU - Kuo, Wen Chuan
AU - Kuo, Yue Ming
AU - Wen, Su Ying
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Non-invasive and quantitative estimations for the delineation of sub-surface tumor margins could greatly aid in the early detection and monitoring of the morphological appearances of tumor growth, ensure complete tumor excision without the unnecessary sacrifice of healthy tissue, and facilitate post-operative follow-up for recurrence. In this study, a high-speed, non-invasive, and ultra-high-resolution spectral domain optical coherence tomography (UHR-SDOCT) imaging platform was developed for the quantitative measurement of human sub-surface skin mass. With a proposed robust, semi-automatic analysis, the system can rapidly quantify lesion area and shape regularity by an en-face-oriented algorithm. Various sizes of nylon sutures embedded in pork skin were used first as a phantom to verify the accuracy of our algorithm, and then in vivo, feasibility was proven using benign human angiomas and pigmented nevi. Clinically, this is the first step towards an automated skin lesion measurement system.
AB - Non-invasive and quantitative estimations for the delineation of sub-surface tumor margins could greatly aid in the early detection and monitoring of the morphological appearances of tumor growth, ensure complete tumor excision without the unnecessary sacrifice of healthy tissue, and facilitate post-operative follow-up for recurrence. In this study, a high-speed, non-invasive, and ultra-high-resolution spectral domain optical coherence tomography (UHR-SDOCT) imaging platform was developed for the quantitative measurement of human sub-surface skin mass. With a proposed robust, semi-automatic analysis, the system can rapidly quantify lesion area and shape regularity by an en-face-oriented algorithm. Various sizes of nylon sutures embedded in pork skin were used first as a phantom to verify the accuracy of our algorithm, and then in vivo, feasibility was proven using benign human angiomas and pigmented nevi. Clinically, this is the first step towards an automated skin lesion measurement system.
KW - Optical coherence tomography
KW - Quantitative measurement
KW - Skin lesions
UR - http://www.scopus.com/inward/record.url?scp=84924235640&partnerID=8YFLogxK
U2 - 10.1002/jbio.201400153
DO - 10.1002/jbio.201400153
M3 - Article
C2 - 25755214
AN - SCOPUS:84924235640
SN - 1864-063X
VL - 9
SP - 343
EP - 350
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 4
ER -