Quantitative analysis on optical properties of human atherosclerosis by using polarization-sensitive optical coherence tomography

Wen Chuan Kuo*, Ming Wei Hsiung, Jeou Jong Shyu, Nai Kuan Chou, Po Nien Yang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In this research, we have used an algorithm to extract four different optical parameters, including the scattering coefficient (μs), effective anisotropy factor (goff), birefringence coefficient (Δn), and fast-axis angle (β) from polarization-sensitive optical coherence tomography (PS-OCT) images. The proposed method was evaluated from a set of phantoms and it yielded valid results. We demonstrate that the optical characteristic of normal and different kinds of atherosclerotic lesions in human vessel can be quantitatively described. Whether change in these quantified optical properties could be used to discriminate between different types of human atherosclerotic plaques was examined.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
DOIs
StatePublished - 2008
EventPhotonic Therapeutics and Diagnostics IV - San Jose, CA, United States
Duration: 19 Jan 200819 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6842
ISSN (Print)1605-7422

Conference

ConferencePhotonic Therapeutics and Diagnostics IV
Country/TerritoryUnited States
CitySan Jose, CA
Period19/01/0819/01/08

Keywords

  • Anisotropy factor
  • Atherosclerosis
  • Fast axis angle
  • Optical coherence tomography
  • Phase retardation
  • Plaque
  • Polarization
  • Scattering coefficient

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