TY - JOUR
T1 - Quantitative analysis of calcium oxalate hydrate urinary stones using FTIR and 950/912 cm−1 peak ratio
AU - Lin, Meng Han
AU - Song, Yu Lin
AU - Lo, Pei An
AU - Hsu, Cheng Yang
AU - Lin, Alex T.L.
AU - Huang, Eric Yi Hsiu
AU - Chiang, Huihua Kenny
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/5
Y1 - 2019/5
N2 - The ability to determine urinary-stone composition is valuable for urologists, allowing them to identify the possible causes of stone formation and to provide appropriate drug treatment and diet-control advice to patients, which can lower recurrence rates. Calcium-based stones account for the majority of urinary stones seen in patients, and calcium oxalate comprises most of these calcium-based stones. This study accomplishes a quantitative analysis of two forms of calcium oxalate stone, those comprised of calcium oxalate monohydrate (COM) or calcium oxalate dihydrate (COD), using Fourier transform infrared spectroscopy (FTIR). The use of a newly validated absorption peak ratio, 950/912 cm−1 (corresponding to COM and COD, respectively), is demonstrated to achieve quantitative estimation of the COM and COD composition. The correlation coefficient between the COM/(COM + COD) composition ratio and the selected peak ratio is 0.99 for standard compound mixtures. This peak-ratio analysis method could aid clinicians in quantitatively determining the COM and COD compositions of calcium oxalate stones, facilitating the design of appropriate treatment plans and preventive measures for calcium-oxalate-stone patients.
AB - The ability to determine urinary-stone composition is valuable for urologists, allowing them to identify the possible causes of stone formation and to provide appropriate drug treatment and diet-control advice to patients, which can lower recurrence rates. Calcium-based stones account for the majority of urinary stones seen in patients, and calcium oxalate comprises most of these calcium-based stones. This study accomplishes a quantitative analysis of two forms of calcium oxalate stone, those comprised of calcium oxalate monohydrate (COM) or calcium oxalate dihydrate (COD), using Fourier transform infrared spectroscopy (FTIR). The use of a newly validated absorption peak ratio, 950/912 cm−1 (corresponding to COM and COD, respectively), is demonstrated to achieve quantitative estimation of the COM and COD composition. The correlation coefficient between the COM/(COM + COD) composition ratio and the selected peak ratio is 0.99 for standard compound mixtures. This peak-ratio analysis method could aid clinicians in quantitatively determining the COM and COD compositions of calcium oxalate stones, facilitating the design of appropriate treatment plans and preventive measures for calcium-oxalate-stone patients.
KW - Calcium oxalate stone
KW - Fourier-transform infrared spectroscopy
KW - Quantitative composition analysis
KW - Urinary stones
UR - http://www.scopus.com/inward/record.url?scp=85065024216&partnerID=8YFLogxK
U2 - 10.1016/j.vibspec.2019.03.006
DO - 10.1016/j.vibspec.2019.03.006
M3 - Article
AN - SCOPUS:85065024216
SN - 0924-2031
VL - 102
SP - 85
EP - 90
JO - Vibrational Spectroscopy
JF - Vibrational Spectroscopy
ER -