Quantitative 3D fluorescence diffuse optical tomography with 3D ultrasound imaging registration in small animal study

Chen Yu Liu, Shih Po Su, Pei An Lo, Hui Hua Kenny Chiang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

An innovative dual-modality 3D fluorescence/3D ultrasound tomography system was demonstrated in this research. The system includes an electron-multiplying charge-coupled device (EMCCD), a 660 nm wavelength fiber-coupling laser, and a 10-15 MHz frequency customized single-element ultrasound transducer on a 3D rotating scanning device. We combined multiple ultrasound images from different sections to obtain a whole-body 3D mesh of mice, which provide anatomical information. In this study, we demonstrated the accuracy of this system through a 4T1 tumor-bearing nude mice experiment.

Original languageEnglish
Title of host publicationUnconventional Optical Imaging II
EditorsCorinne Fournier, Marc P. Georges, Gabriel Popescu
PublisherSPIE
ISBN (Electronic)9781510634749
DOIs
StatePublished - 2020
EventUnconventional Optical Imaging II 2020 - Virtual, Online, France
Duration: 6 Apr 202010 Apr 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11351
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceUnconventional Optical Imaging II 2020
Country/TerritoryFrance
CityVirtual, Online
Period6/04/2010/04/20

Keywords

  • 3D ultrasound
  • Dual-modality imaging
  • Fluorescence
  • Optical diffuse tomography
  • Small animal

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