Quantification of structural and microvascular changes for diagnosing early-stage oral cancer

Ping Hsien Chen; Yu Ju Chen; Yi Fen Chen; Yi Chen Yeh; Kuo Wei Chang; Ming Chih Hou; Wen Chuan Kuo

doi:10.1364/BOE.384608

Quantification of structural and microvascular changes for diagnosing early-stage oral cancer

Ping Hsien Chen, Yu Ju Chen, Yi Fen Chen, Yi Chen Yeh, Kuo Wei Chang, Ming Chih Hou, Wen Chuan Kuo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Changes in mucosal microvascular networks, called intraepithelial papillary capillary loops (IPCL), are an important key factor for diagnosing early-stage oral cancer in vivo. Nevertheless, there are a lack of tools to quantify these changes objectively. This is the first study to quantify the IPCL changes in vivo to differentiate benign or malignant oral lesions by the optical coherence tomography (OCT) technique. K14-EGFP-miR-211-GFP transgenic mice were inducted by 4-Nitroquinoline-1-oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. The results showed significant differentiation between benign or malignant lesions by OCT quantitative parameters, including epithelial thickness, IPCL density, radius and tortuosity.

Original language	English
Pages (from-to)	1244-1256
Number of pages	13
Journal	Biomedical Optics Express
Volume	11
Issue number	3
DOIs	https://doi.org/10.1364/BOE.384608
State	Published - 1 Mar 2020

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title = "Quantification of structural and microvascular changes for diagnosing early-stage oral cancer",

abstract = "Changes in mucosal microvascular networks, called intraepithelial papillary capillary loops (IPCL), are an important key factor for diagnosing early-stage oral cancer in vivo. Nevertheless, there are a lack of tools to quantify these changes objectively. This is the first study to quantify the IPCL changes in vivo to differentiate benign or malignant oral lesions by the optical coherence tomography (OCT) technique. K14-EGFP-miR-211-GFP transgenic mice were inducted by 4-Nitroquinoline-1-oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. The results showed significant differentiation between benign or malignant lesions by OCT quantitative parameters, including epithelial thickness, IPCL density, radius and tortuosity.",

author = "Chen, {Ping Hsien} and Chen, {Yu Ju} and Chen, {Yi Fen} and Yeh, {Yi Chen} and Chang, {Kuo Wei} and Hou, {Ming Chih} and Kuo, {Wen Chuan}",

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T1 - Quantification of structural and microvascular changes for diagnosing early-stage oral cancer

AU - Chen, Ping Hsien

AU - Chen, Yu Ju

AU - Chen, Yi Fen

AU - Yeh, Yi Chen

AU - Chang, Kuo Wei

AU - Hou, Ming Chih

AU - Kuo, Wen Chuan

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Changes in mucosal microvascular networks, called intraepithelial papillary capillary loops (IPCL), are an important key factor for diagnosing early-stage oral cancer in vivo. Nevertheless, there are a lack of tools to quantify these changes objectively. This is the first study to quantify the IPCL changes in vivo to differentiate benign or malignant oral lesions by the optical coherence tomography (OCT) technique. K14-EGFP-miR-211-GFP transgenic mice were inducted by 4-Nitroquinoline-1-oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. The results showed significant differentiation between benign or malignant lesions by OCT quantitative parameters, including epithelial thickness, IPCL density, radius and tortuosity.

AB - Changes in mucosal microvascular networks, called intraepithelial papillary capillary loops (IPCL), are an important key factor for diagnosing early-stage oral cancer in vivo. Nevertheless, there are a lack of tools to quantify these changes objectively. This is the first study to quantify the IPCL changes in vivo to differentiate benign or malignant oral lesions by the optical coherence tomography (OCT) technique. K14-EGFP-miR-211-GFP transgenic mice were inducted by 4-Nitroquinoline-1-oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. The results showed significant differentiation between benign or malignant lesions by OCT quantitative parameters, including epithelial thickness, IPCL density, radius and tortuosity.

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Quantification of structural and microvascular changes for diagnosing early-stage oral cancer

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