Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Wei Lun Chiang; Cherng Jyh Ke; Zi Xian Liao; San-Yuan Chen; Fu Rong Chen; Chun Ying Tsai; Younan Xia; Hsing Wen Sung

doi:10.1002/smll.201201743

Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Wei Lun Chiang, Cherng Jyh Ke, Zi Xian Liao, San-Yuan Chen, Fu Rong Chen, Chun Ying Tsai, Younan Xia^*, Hsing Wen Sung

^*Corresponding author for this work

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T _g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.

Original language	English
Pages (from-to)	3584-3588
Number of pages	5
Journal	Small
Volume	8
Issue number	23
DOIs	https://doi.org/10.1002/smll.201201743
State	Published - 7 Dec 2012

Keywords

iron oxide nanoparticles
magnetic stimulus
molecular switches
pulsatile drug release

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10.1002/smll.201201743

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abstract = "Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.",

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AU - Chiang, Wei Lun

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AU - Chen, San-Yuan

AU - Chen, Fu Rong

AU - Tsai, Chun Ying

AU - Xia, Younan

AU - Sung, Hsing Wen

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AB - Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.

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Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

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Keywords

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