Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation

Jen Tsun Lin; Ming Yang Lee; Lian Tsai Hsiao; Mu Hua Yang; Ta Chon Chao; Po Min Chen; Tzeon Jye Chiou

doi:10.1007/s00277-003-0813-z

Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation

Jen Tsun Lin, Ming Yang Lee, Lian Tsai Hsiao, Mu Hua Yang, Ta Chon Chao, Po Min Chen, Tzeon Jye Chiou^*

^*Corresponding author for this work

Institute of Clinical Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We describe a case of pulmonary nocardiosis in a female patient with graft-versus-host disease (GVHD) underwent therapy with imatinib mesylate for a relapse of chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT). The patient developed chronic GVHD 8 months after the use of imatinib and was on corticosteroid therapy. Three months after the development of chronic GVHD, she acquired pulmonary nocardiosis and a computed tomography (CT) scan of the chest showed multiple nodular lesions with cavitations over both lungs. She was successfully treated with single-agent trimethoprim-sulfamethoxazole (TMP/SMX) and the infection did not recur. Our case indicated that pulmonary nocardiosis could occur in patients with GVHD undergoing imatinib and corticosteroid therapy and might be treated by single-agent TMP/SMX.

Original language	English
Pages (from-to)	444-446
Number of pages	3
Journal	Annals of Hematology
Volume	83
Issue number	7
DOIs	https://doi.org/10.1007/s00277-003-0813-z
State	Published - Jul 2004

Keywords

Bone marrow transplantation
Imatinib mesylate
Nocardiosis

Access to Document

10.1007/s00277-003-0813-z

Cite this

@article{92f42a8c9b374232b86990a656adc5cb,

title = "Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation",

abstract = "We describe a case of pulmonary nocardiosis in a female patient with graft-versus-host disease (GVHD) underwent therapy with imatinib mesylate for a relapse of chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT). The patient developed chronic GVHD 8 months after the use of imatinib and was on corticosteroid therapy. Three months after the development of chronic GVHD, she acquired pulmonary nocardiosis and a computed tomography (CT) scan of the chest showed multiple nodular lesions with cavitations over both lungs. She was successfully treated with single-agent trimethoprim-sulfamethoxazole (TMP/SMX) and the infection did not recur. Our case indicated that pulmonary nocardiosis could occur in patients with GVHD undergoing imatinib and corticosteroid therapy and might be treated by single-agent TMP/SMX.",

keywords = "Bone marrow transplantation, Imatinib mesylate, Nocardiosis",

author = "Lin, {Jen Tsun} and Lee, {Ming Yang} and Hsiao, {Lian Tsai} and Yang, {Mu Hua} and Chao, {Ta Chon} and Chen, {Po Min} and Chiou, {Tzeon Jye}",

year = "2004",

month = jul,

doi = "10.1007/s00277-003-0813-z",

language = "English",

volume = "83",

pages = "444--446",

journal = "Annals of Hematology",

issn = "0939-5555",

publisher = "Springer Verlag",

number = "7",

}

TY - JOUR

T1 - Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation

AU - Lin, Jen Tsun

AU - Lee, Ming Yang

AU - Hsiao, Lian Tsai

AU - Yang, Mu Hua

AU - Chao, Ta Chon

AU - Chen, Po Min

AU - Chiou, Tzeon Jye

PY - 2004/7

Y1 - 2004/7

N2 - We describe a case of pulmonary nocardiosis in a female patient with graft-versus-host disease (GVHD) underwent therapy with imatinib mesylate for a relapse of chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT). The patient developed chronic GVHD 8 months after the use of imatinib and was on corticosteroid therapy. Three months after the development of chronic GVHD, she acquired pulmonary nocardiosis and a computed tomography (CT) scan of the chest showed multiple nodular lesions with cavitations over both lungs. She was successfully treated with single-agent trimethoprim-sulfamethoxazole (TMP/SMX) and the infection did not recur. Our case indicated that pulmonary nocardiosis could occur in patients with GVHD undergoing imatinib and corticosteroid therapy and might be treated by single-agent TMP/SMX.

AB - We describe a case of pulmonary nocardiosis in a female patient with graft-versus-host disease (GVHD) underwent therapy with imatinib mesylate for a relapse of chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT). The patient developed chronic GVHD 8 months after the use of imatinib and was on corticosteroid therapy. Three months after the development of chronic GVHD, she acquired pulmonary nocardiosis and a computed tomography (CT) scan of the chest showed multiple nodular lesions with cavitations over both lungs. She was successfully treated with single-agent trimethoprim-sulfamethoxazole (TMP/SMX) and the infection did not recur. Our case indicated that pulmonary nocardiosis could occur in patients with GVHD undergoing imatinib and corticosteroid therapy and might be treated by single-agent TMP/SMX.

KW - Bone marrow transplantation

KW - Imatinib mesylate

KW - Nocardiosis

UR - http://www.scopus.com/inward/record.url?scp=3042857521&partnerID=8YFLogxK

U2 - 10.1007/s00277-003-0813-z

DO - 10.1007/s00277-003-0813-z

M3 - Article

C2 - 14689232

AN - SCOPUS:3042857521

SN - 0939-5555

VL - 83

SP - 444

EP - 446

JO - Annals of Hematology

JF - Annals of Hematology

IS - 7

ER -

Pulmonary nocardiosis in a patient with CML relapse undergoing imatinib therapy after bone marrow transplantation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this