Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes

Y. T. Chang*, C. T. Chou, Y. M. Shiao, M. W. Lin, C. W. Yu, C. C. Chen, C. H. Huang, D. D. Lee, H. N. Liu, W. J. Wang, S. F. Tsai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Background: Besides the HLA-Cw*0602 allele, the psoriasis susceptibility 1 candidate 3 (PSORS1C3) and corneodesmosin (CDSN) genes are two probable psoriasis susceptibility genes in the PSORS1 locus. The -79C, -26C and +246A alleles of the PSORS1C3 gene, the CDSN*971T allele, CDSN*TTC (619T-1236T-1243C) and CDSN*5 (619T-1240G-1243C) are strongly associated with psoriasis in the caucasian population. Until now, no haplotype study of the PSORS1C3 and CDSN genes has been documented in Chinese patients with psoriasis vulgaris. Objectives: We aimed to determine whether genetic polymorphisms of the PSORS1C3 and CDSN genes were associated with an increased risk of psoriasis vulgaris in Chinese patients in Taiwan. Methods: We investigated the PSORS1C3 and CDSN genes for disease association by direct sequencing in 178 patients with psoriasis vulgaris and 203 control subjects. Genotyping for HLA-Cw*0602, α-helix coiled-coil rod homologue (HCR) gene and single nucleotide polymorphism (SNP) n.9 was also carried out using a sequence-based typing method. Results: The PSORS1C3*582A allele, an SNP in the 3′-untranslated region of the PSORS1C3 gene, was a major psoriasis vulgaris susceptibility allele in the Chinese population, and the association was much stronger in patients with early-onset psoriasis vulgaris (22.3% vs. 6.9%, odds ratio = 3.87, Pc =0.0000072). The frequencies of CDSN*TTC and CDSN*971T were also significantly increased in patients with early-onset psoriasis vulgaris. Moreover, PSORS1C3*582A, SNP n.9*C, Cw*0602 and HCR*WWCC were in near complete linkage disequilibrium (LD) with each other; in contrast, the LD with the CDSN gene was not so strong. SNP n.9*C-Cw*0602-PSORS1C3*582A-HCR*WWCC was a major susceptibility haplotype in patients with early-onset psoriasis vulgaris (P < 10-7) and this risk haplotype also carried CDSN*TTC and CDSN*971T. Conclusions: The PSORS1C3 and CDSN genes are important psoriasis susceptibility genes in Chinese patients with psoriasis vulgaris.

Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalBritish Journal of Dermatology
Volume155
Issue number4
DOIs
StatePublished - Oct 2006

Keywords

  • Chinese
  • Corneodesmosin gene
  • HLA-Cw*0602
  • Psoriasis susceptibility 1 candidate 3 gene
  • Psoriasis vulgaris
  • α-helix coiled-coil rod homologue gene

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