Protein tyrosine-phosphatase expression profiling in gastric cancer tissues

Chew Wun Wu; Hwa Li Kao; Anna F.Y. Li; Chin Wen Chi; Wen chang Lin

doi:10.1016/j.canlet.2005.10.046

Protein tyrosine-phosphatase expression profiling in gastric cancer tissues

Chew Wun Wu, Hwa Li Kao, Anna F.Y. Li, Chin Wen Chi, Wen chang Lin^*

^*Corresponding author for this work

Department of Pathology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.

Original language	English
Pages (from-to)	95-103
Number of pages	9
Journal	Cancer Letters
Volume	242
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.10.046
State	Published - 8 Oct 2006

Keywords

Expression profile
Gastric cancer
Immunohistochemistry
Protein tyrosine-phosphatase

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10.1016/j.canlet.2005.10.046

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title = "Protein tyrosine-phosphatase expression profiling in gastric cancer tissues",

abstract = "Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.",

keywords = "Expression profile, Gastric cancer, Immunohistochemistry, Protein tyrosine-phosphatase",

author = "Wu, {Chew Wun} and Kao, {Hwa Li} and Li, {Anna F.Y.} and Chi, {Chin Wen} and Lin, {Wen chang}",

note = "Funding Information: The authors are grateful to Drs Daniel Robinson, Hua-Chien Chen and Hsing-Jien Kung (University of California, Davis) for the development of the PTP profile approach and their continuing support. We would like to thank Dr Chun-houh Chen for his advice on statistical analysis; as well as Jyh-Shi Lin, Wenni Su, Chun-Hung Lai and Hsiao-Wei Kao for their excellent technical assistance. This study was supported in part by grants from Academia Sinica and the National Science Council (NSC 90-2314-B-001-002-M58 and NSC 91-2321-B-001-009). ",

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doi = "10.1016/j.canlet.2005.10.046",

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AU - Wu, Chew Wun

AU - Kao, Hwa Li

AU - Li, Anna F.Y.

AU - Chi, Chin Wen

AU - Lin, Wen chang

N1 - Funding Information: The authors are grateful to Drs Daniel Robinson, Hua-Chien Chen and Hsing-Jien Kung (University of California, Davis) for the development of the PTP profile approach and their continuing support. We would like to thank Dr Chun-houh Chen for his advice on statistical analysis; as well as Jyh-Shi Lin, Wenni Su, Chun-Hung Lai and Hsiao-Wei Kao for their excellent technical assistance. This study was supported in part by grants from Academia Sinica and the National Science Council (NSC 90-2314-B-001-002-M58 and NSC 91-2321-B-001-009).

PY - 2006/10/8

Y1 - 2006/10/8

N2 - Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.

AB - Protein phosphorylation is an important regulatory mechanism involved in signal transduction and cancers. In comparison to the extensive tyrosine-kinase oncogenesis research, there are only relatively few studies of protein tyrosine-phosphatase expression in cancers. The expression profile for tyrosine-phosphatases was investigated in gastric cancers using RT-PCR and molecular cloning. The present study showed a general PTP expression profile in gastric cancer tissues, with the identification of 22 distinct tyrosine-phosphatases. Following the examination of five PTPs (PTPRA, PTPRB, PTPRD, PTPRG and PTPRZ) using immunohistochemistry, strong association was observed between PTPRA/PTPRZ expression and gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination.

KW - Expression profile

KW - Gastric cancer

KW - Immunohistochemistry

KW - Protein tyrosine-phosphatase

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SN - 0304-3835

VL - 242

SP - 95

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JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Protein tyrosine-phosphatase expression profiling in gastric cancer tissues

Abstract

Keywords

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