Prognosis of non-small-cell lung cancer with unexpected pleural spread at thoracotomy

Bing Yen Wang, Yu Chung Wu, Jung Jyh Hung, Po Kuei Hsu, Chih Cheng Hsieh, Chien Sheng Huang, Wen Hu Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: The aim of the study is to investigate the prognosis of non-small-cell lung cancer (NSCLC) with unexpected pleural spread at thoracotomy. Materials and Methods: We conducted a retrospective review of the clinicopathologic characteristics of NSCLC patients with unexpected pleural spread at thoracotomy in Taipei Veterans General Hospital between January 1990 and December 2008. Inclusion criteria were patients with frozen section of pleural nodules identified as metastatic carcinoma during operation. A survival analysis was done. Results: There were 138 patients included in this study. The median follow-up time was 19.9 mo. The overall 1, 3, and 5-year survival rates were 72.9%, 26.8%, and 16.6%, respectively. Multivariate analysis showed that main tumor resection and mediastinal lymph nodal involvement (P < 0.001 and 0.002, respectively) were significant predictors for overall survival rate. Patients who underwent main tumor resection and those without mediastinal lymph node metastasis had better outcomes. Conclusions: Among the unexpected pleural spread detected at thoracotomy, limited pulmonary resection was an alternative surgical procedure for these patients without mediastinal nodal metastasis.

Original languageEnglish
Pages (from-to)e1
JournalJournal of Surgical Research
Volume169
Issue number1
DOIs
StatePublished - Jul 2011

Keywords

  • lung cancer
  • mediastinal lymph nodes
  • pleural spread
  • surgical resection

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