Primary structure and developmental expression of zebrafish sodium channel Nav1.6 during neurogenesis

C. W. Tsai, J. J. Tseng, S. C. Lin, C. Y. Chang, J. L. Wu, J. F. Horng, H. J. Tsay*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A zebrafish sodium channel cDNA encoding a 1949-amino acid polypeptide, Nav1.6, was isolated. Two transcripts were detected in zebrafish adult brain but not in cardiac or skeletal muscle. The RNase protection analysis confirmed the neural specificity of zebrafish Nav1.6 24 hours postfertilization (hpf) Nav1.6 was expressed in the trigeminal ganglion, anterior and posterior lateral line ganglia, rhombomeres, and Rohon-Beard neurons. This preferential localization suggests that Nav1.6 plays an important role in tactile sensitivity. The abundance of zebrafish Nav1.6 mRNA in the central and peripheral nervous systems increased markedly between 48 and 72 hpf, during the maturation of the nervous system.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalDNA and Cell Biology
Volume20
Issue number5
DOIs
StatePublished - 2001

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