Primary Small Cell Carcinoma of the Stomach Successfully Treated With Cisplatin and Etoposide

Shu Chen Kuo, Yee Chao, Jiing Chyuan Luo, Kuei Chuan Lee, Chew Wun Wu, Anna Fen Yau Li, Rheun Chuan Lee, Chung Pin Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We report a 44-year-old man with primary gastric small cell carcinoma who showed a remarkable response to chemotherapy specific for pulmonary small cell carcinoma. The patient had been admitted to another local hospital because of intermittent epigastralgia. An upper gastrointestinal examination there revealed an ulcerative tumor, 5 cm in diameter, on the lesser curvature side of the cardia, and endoscopic biopsy reported adenocarcinoma. Computed tomography revealed a mass over the lesser curvature of the stomach and some enlarged regional lymph nodes. Radical total gastrectomy, lymph node dissection, Roux-en-Y esophagojejunostomy and splenectomy were performed at our hospital. Pathology revealed gastric mucosa infiltrated by small-sized tumor cells with scanty cytoplasm and hyperchromatic nuclei. Immunohisto- chemically, the tumor cells were positive for synaptophysin, chromogranin A, and CD56. Primary gastric small cell carcinoma was diagnosed. The postoperative course, complicated by shock due to bleeding, wound infection and intra-abdominal abscess, took more than 2 months to resolve. Follow-up computed tomography showed tumor recurrence with multiple enlarged lymph nodes in the aortocaval region and hepatic hilum. The patient received palliative chemotherapy consisting of cisplatin 80 mg/m2 on day 1 and etoposide 80 mg/m2 on days 1-3 every 28 days, and had partial response to the chemotherapy, with a progression-free survival of 10 months. Chemotherapy with cisplatin and etoposide used for small cell carcinoma of the lung is a good treatment for gastric small cell carcinoma.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalJournal of the Chinese Medical Association
Issue number11
StatePublished - Nov 2009


  • chemotherapy
  • small cell carcinoma
  • stomach


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