Primary sjögren's syndrome associated with Gitelman's syndrome presenting with muscular paralysis

Yen Cheng Chen, Wu Chang Yang, An Han Yang, Shih Hua Lin, Hsin Yu Li, Chih Ching Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


A 38-year-old woman presented with muscle cramping of 4 extremities and paralysis for months. Laboratory results showed an elevated antinuclear antibody titer; antibodies to the ribonucleoprotein antigen Ro; hypokalemia; hypomagnesemia with hyperreninemia, but abnormally high urine potassium and magnesium levels and low urine calcium levels; and a blunted diuretic effect to thlazide, but not furosemide, which met the criteria for Gitelman's syndrome (GS) and led to the diagnosis of primary Sjögren's syndrome (pSS). She received medical treatment, including a potassium supplement and aldosterone antagonist. GS as a presentation of pSS has never been reported in the literature. The features of renal diseases related to SS are reviewed. SS is the underlying cause of GS, which may precede the onset of the well-known sicca complex.

Original languageEnglish
Pages (from-to)586-590
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number3
StatePublished - 1 Sep 2003


  • Furosemide
  • Gitelman's syndrome (GS)
  • Sjögren's syndrome (SS)
  • Sodium-chloride (Na/Cl) cotransporter (NCCT)
  • Thiazide
  • Tubulointerstitial nephritis


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