TY - JOUR
T1 - Prevalence of antilipemic drug use in Taiwan
T2 - Analysis of a sampling cohort within the National Health Insurance
AU - Chen, Tzeng Ji
AU - Lin, Shing Jong
AU - Chen, Liang Kung
AU - Hwang, Shinn Jang
AU - Chou, Li Fang
PY - 2003/1
Y1 - 2003/1
N2 - Background. Hyperlipidemia is a major risk factor of cardiovascular diseases. We investigated the utilization of antilipemic drugs at the outpatient sector within the National Health Insurance in Taiwan. Methods. We obtained the first cohort (n = 50,000) dataset from the National Health Insurance Research Database and analyzed the outpatient claim files of the cohort in 2000. The antilipemic drugs were defined as the drug items belonging to the group C10 (serum lipid reducing agents) of the Anatomical Therapeutic Chemical classification system. Results. Among the cohort with 46,614 eligible people, 760 patients had ever received antilipemic drugs (prevalence: 1.6%). The group 60 - 69 years of age had the greatest age-specific prevalence (7.2%), followed by the group over 70 years of age (6.0%). There were more male than female patients, but female patients outnumbered male patients before the age of 49 years. The antilipemic drugs had been prescribed 3,850 times totally with 70,272 defined daily doses (DDDs). On an average, a patient with antilipemic therapy received 5.1 (± 4.5) prescriptions of antilipemic drugs in one year and a prescription contained 18.3 (± 11.5) DDDs. We measured 4.1 DDDs per 1,000 inhabitants per day for all antilipemic drug use in 2000. The statins and fibrates predominated the antilipemic drug use. While gemfibrozil was most popular in respect of recipients and prescription items, simvastatin had the largest amount of use in unit of DDDs. Diabetes mellitus co-existed in 37.8% of the patients with antilipemic therapy and the standardized morbidity ratio (SMR) was 3.34. The other concomitant diseases included essential hypertension (rate: 48.8%, SMR: 2.40) and other heart disease (rate: 30.7%, SMR: 2.36). Conclusions. Statins were the leading antilipemic drugs in Taiwan. The users of antilipemic drugs were more likely to have concomitant diabetes mellitus, hypertension and heart disease.
AB - Background. Hyperlipidemia is a major risk factor of cardiovascular diseases. We investigated the utilization of antilipemic drugs at the outpatient sector within the National Health Insurance in Taiwan. Methods. We obtained the first cohort (n = 50,000) dataset from the National Health Insurance Research Database and analyzed the outpatient claim files of the cohort in 2000. The antilipemic drugs were defined as the drug items belonging to the group C10 (serum lipid reducing agents) of the Anatomical Therapeutic Chemical classification system. Results. Among the cohort with 46,614 eligible people, 760 patients had ever received antilipemic drugs (prevalence: 1.6%). The group 60 - 69 years of age had the greatest age-specific prevalence (7.2%), followed by the group over 70 years of age (6.0%). There were more male than female patients, but female patients outnumbered male patients before the age of 49 years. The antilipemic drugs had been prescribed 3,850 times totally with 70,272 defined daily doses (DDDs). On an average, a patient with antilipemic therapy received 5.1 (± 4.5) prescriptions of antilipemic drugs in one year and a prescription contained 18.3 (± 11.5) DDDs. We measured 4.1 DDDs per 1,000 inhabitants per day for all antilipemic drug use in 2000. The statins and fibrates predominated the antilipemic drug use. While gemfibrozil was most popular in respect of recipients and prescription items, simvastatin had the largest amount of use in unit of DDDs. Diabetes mellitus co-existed in 37.8% of the patients with antilipemic therapy and the standardized morbidity ratio (SMR) was 3.34. The other concomitant diseases included essential hypertension (rate: 48.8%, SMR: 2.40) and other heart disease (rate: 30.7%, SMR: 2.36). Conclusions. Statins were the leading antilipemic drugs in Taiwan. The users of antilipemic drugs were more likely to have concomitant diabetes mellitus, hypertension and heart disease.
KW - Antilipemic agents
KW - Drug utilization
KW - National health programs
KW - Pharmacoepidemiology
KW - Prevalence
UR - http://www.scopus.com/inward/record.url?scp=0038657963&partnerID=8YFLogxK
M3 - Article
C2 - 12728973
AN - SCOPUS:0038657963
SN - 1726-4901
VL - 66
SP - 39
EP - 45
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 1
ER -
