Presence and Progression of Abdominal Obesity Are Predictors of Future High Blood Pressure and Hypertension

Shao Yuan Chuang, Pesus Chou, Pai Feng Hsu, Hao Min Cheng, Shih Tzer Tsai, I. Feng Lin, Chen Huan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Background: General obesity and its progression are major predictors of future hypertension. It has not been established whether abdominal obesity contributes to the development of hypertension. Methods: A community-based study population of 2377 normotensive nondiabetic Chinese adults aged ≥30 years were re-examined 10 years after their baseline examination. Results: The 10-year cumulative incidence of hypertension was 25.9%. The standardized parameters for the prediction of follow-up systolic blood pressure (BP) for baseline body mass index (BMI), change in BMI, baseline homeostasis model assessment of insulin resistance (HOMA-IR), change in HOMA-IR, baseline waist circumference (WC), and change in WC were 0.19 (P < .001), 0.09 (P < .001), 0.11 (P < .001), 0.08 (P < .001), 0.16 (P < .001), and 0.07 (P < .001), respectively, when age, sex, and baseline systolic BP were accounted for. By stepwise linear regression analysis, age, baseline systolic BP, baseline BMI, change in BMI, baseline WC, and change in WC were significant predictors of the follow-up systolic BP. Both baseline WC and change in WC were significant predictors of follow-up systolic BP or incident hypertension when age, sex, baseline systolic BP, BMI, and change in BMI were accounted for. In a subgroup of younger adults with normal BMI and BP<130/85 mm Hg, baseline systolic BP, change in HOMA-IR, baseline WC, and change in WC were significantly independent predictors of follow-up systolic BP. Conclusion: Abdominal obesity and its progression are predictors of future BP and hypertension incidence, independent of the effects of general obesity.

Original languageEnglish
Pages (from-to)788-795
Number of pages8
JournalAmerican Journal of Hypertension
Volume19
Issue number8
DOIs
StatePublished - Aug 2006

Keywords

  • Hypertension
  • insulin resistance
  • obesity

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