Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

Hsieh Chih Tsai; Hsiao Ying Chou; Shun Hao Chuang; Juin Yih Lai; Yi Shu Chen; Yu Han Wen; Lu Yi Yu; Chun Liang Lo

doi:10.3390/polym11101592

Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

Hsieh Chih Tsai^*, Hsiao Ying Chou, Shun Hao Chuang, Juin Yih Lai, Yi Shu Chen, Yu Han Wen, Lu Yi Yu, Chun Liang Lo

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice.

Original language	English
Article number	1592
Journal	Polymers
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/polym11101592
State	Published - 1 Oct 2019

Keywords

Immunotherapy
Injectable
Liposomes
Temperature-sensitive hydrogel

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/polym11101592

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title = "Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer",

abstract = "To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice.",

keywords = "Immunotherapy, Injectable, Liposomes, Temperature-sensitive hydrogel",

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T1 - Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

AU - Tsai, Hsieh Chih

AU - Chou, Hsiao Ying

AU - Chuang, Shun Hao

AU - Lai, Juin Yih

AU - Chen, Yi Shu

AU - Wen, Yu Han

AU - Yu, Lu Yi

AU - Lo, Chun Liang

PY - 2019/10/1

Y1 - 2019/10/1

N2 - To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice.

AB - To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice.

KW - Immunotherapy

KW - Injectable

KW - Liposomes

KW - Temperature-sensitive hydrogel

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DO - 10.3390/polym11101592

M3 - Article

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SN - 2073-4360

VL - 11

JO - Polymers

JF - Polymers

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ER -

Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

Abstract

Keywords

UN SDGs

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