Preparation and cytotoxic effect of ceanothic acid derivatives

Shoei Sheng Lee; Wen Chuan Chen; Chih Fen Huang; Yeu Su

doi:10.1021/np9800856

Preparation and cytotoxic effect of ceanothic acid derivatives

Shoei Sheng Lee^*, Wen Chuan Chen, Chih Fen Huang, Yeu Su

^*Corresponding author for this work

Institute of Biopharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC₅₀ of 2.8 and 6.6 μg/mL, respectively, and an IC₅₀ of 11.3 μg/mL against normal cell line FS-5.

Original language	English
Pages (from-to)	1343-1347
Number of pages	5
Journal	Journal of Natural Products
Volume	61
Issue number	11
DOIs	https://doi.org/10.1021/np9800856
State	Published - Nov 1998

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title = "Preparation and cytotoxic effect of ceanothic acid derivatives",

abstract = "Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.",

author = "Lee, {Shoei Sheng} and Chen, {Wen Chuan} and Huang, {Chih Fen} and Yeu Su",

year = "1998",

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AU - Chen, Wen Chuan

AU - Huang, Chih Fen

AU - Su, Yeu

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N2 - Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.

AB - Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Preparation and cytotoxic effect of ceanothic acid derivatives

Abstract

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