Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

Ging Ho Hsiue*, Chun Liang Lo, Ching Hao Cheng, Che Ping Lin, Chun Kai Huang, Hung Hao Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).

Original languageEnglish
Pages (from-to)688-698
Number of pages11
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number4
StatePublished - 15 Feb 2007


  • Atom transfer radical polymerization (ATRP)
  • Diblock copolymers
  • Nanoparticles
  • Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)
  • Poly(D,L-lactide) (PLA)


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