A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).
|Number of pages||11|
|Journal||Journal of Polymer Science, Part A: Polymer Chemistry|
|State||Published - 15 Feb 2007|
- Atom transfer radical polymerization (ATRP)
- Diblock copolymers
- Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)
- Poly(D,L-lactide) (PLA)