Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

Ging Ho Hsiue; Chun Liang Lo; Ching Hao Cheng; Che Ping Lin; Chun Kai Huang; Hung Hao Chen

doi:10.1002/pola.21741

Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

Ging Ho Hsiue^*, Chun Liang Lo, Ching Hao Cheng, Che Ping Lin, Chun Kai Huang, Hung Hao Chen

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by ¹H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).

Original language	English
Pages (from-to)	688-698
Number of pages	11
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	45
Issue number	4
DOIs	https://doi.org/10.1002/pola.21741
State	Published - 15 Feb 2007

Keywords

Atom transfer radical polymerization (ATRP)
Diblock copolymers
Nanoparticles
Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)
Poly(D,L-lactide) (PLA)

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10.1002/pola.21741

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title = "Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles",

abstract = "A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).",

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AU - Hsiue, Ging Ho

AU - Lo, Chun Liang

AU - Cheng, Ching Hao

AU - Lin, Che Ping

AU - Huang, Chun Kai

AU - Chen, Hung Hao

PY - 2007/2/15

Y1 - 2007/2/15

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AB - A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by 1H NMR, atomic force microscopy, and ζ-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)- block-poly(D,L-lactide).

KW - Atom transfer radical polymerization (ATRP)

KW - Diblock copolymers

KW - Nanoparticles

KW - Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)

KW - Poly(D,L-lactide) (PLA)

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JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 4

ER -

Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylcholine)-block-poly(D,L-lactide) polymer nanoparticles

Abstract

Keywords

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