Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

Shih Cheng Chen; Ming Hui Yang; Tze Wen Chung; Ting Syuan Jhuang; Jean Dean Yang; Ko Chin Chen; Wan Jou Chen; Ying Fong Huang; Shiang Bin Jong; Wan Chi Tsai; Po Chiao Lin; Yu Chang Tyan

doi:10.1155/2017/4051763

Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

Shih Cheng Chen, Ming Hui Yang, Tze Wen Chung, Ting Syuan Jhuang, Jean Dean Yang, Ko Chin Chen, Wan Jou Chen, Ying Fong Huang, Shiang Bin Jong, Wan Chi Tsai, Po Chiao Lin, Yu Chang Tyan^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used ¹³¹I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the ¹³¹I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.

Original language	English
Article number	4051763
Journal	BioMed Research International
Volume	2017
DOIs	https://doi.org/10.1155/2017/4051763
State	Published - 2017

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Chen, S. C., Yang, M. H., Chung, T. W., Jhuang, T. S., Yang, J. D., Chen, K. C., Chen, W. J., Huang, Y. F., Jong, S. B., Tsai, W. C., Lin, P. C., & Tyan, Y. C. (2017). Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol. BioMed Research International, 2017, Article 4051763. https://doi.org/10.1155/2017/4051763

@article{077d7cb433774ae4aa60808f69c27334,

title = "Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol",

abstract = "Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.",

author = "Chen, {Shih Cheng} and Yang, {Ming Hui} and Chung, {Tze Wen} and Jhuang, {Ting Syuan} and Yang, {Jean Dean} and Chen, {Ko Chin} and Chen, {Wan Jou} and Huang, {Ying Fong} and Jong, {Shiang Bin} and Tsai, {Wan Chi} and Lin, {Po Chiao} and Tyan, {Yu Chang}",

note = "Publisher Copyright: {\textcopyright} 2017 Shih-Cheng Chen et al.",

year = "2017",

doi = "10.1155/2017/4051763",

language = "English",

volume = "2017",

journal = "BioMed Research International",

issn = "2314-6133",

publisher = "John Wiley and Sons Ltd",

}

Chen, SC, Yang, MH, Chung, TW, Jhuang, TS, Yang, JD, Chen, KC, Chen, WJ, Huang, YF, Jong, SB, Tsai, WC, Lin, PC & Tyan, YC 2017, 'Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol', BioMed Research International, vol. 2017, 4051763. https://doi.org/10.1155/2017/4051763

TY - JOUR

T1 - Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

AU - Chen, Shih Cheng

AU - Yang, Ming Hui

AU - Chung, Tze Wen

AU - Jhuang, Ting Syuan

AU - Yang, Jean Dean

AU - Chen, Ko Chin

AU - Chen, Wan Jou

AU - Huang, Ying Fong

AU - Jong, Shiang Bin

AU - Tsai, Wan Chi

AU - Lin, Po Chiao

AU - Tyan, Yu Chang

PY - 2017

Y1 - 2017

N2 - Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.

AB - Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.

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SN - 2314-6133

VL - 2017

JO - BioMed Research International

JF - BioMed Research International

M1 - 4051763

ER -

Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

Abstract

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