Predicting the risk of cardiovascular disease in people exposed to moderate to high levels of dioxin

Jung Wei Chang, Hsiu Ling Chen, Chih Ching Chang, Huey Jen Su, Po Chi Liao, Ching Chang Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Dioxins can cause cardiovascular toxicity in experimental animals. The potential role of dioxin exposure as a preventable risk factor has attracted the attention of public health services, especially because dioxin exposure is a ubiquitous problem. We aimed to investigate and clarify the effect on CVD risk of moderate-to-high exposure to dioxins. This cross-sectional study investigated 914 residents without CVD near a deserted pentachlorophenol factory. CVD-related factors were measured to examine their associations with serum dioxin. We also investigated associations between serum dioxins and the Framingham risk score. Serum PCDD/F levels were significantly positively associated with CVD risk in both genders (Men: b=0.023, P<0.001; Women: b=0.005, P<0.001; All: b=0.013, P<0.001). After adjusting for confounding factors, participants with higher serum PCDD/F levels had a higher risk for CVD than did the reference group (serum PCDD/levels<9.8pg WHO 98-TEQ DF/g lipid) (25th to <50th percentile, adjusted odds ratio (AOR)=2.96 [95% confidence interval (CI)=1.13-7.75]; 50th to<75th percentile, AOR=3.37 [1.32-8.59]; ≥75th percentile, AOR=6.22 [2.47-15.63]). We hypothesize that accumulated dioxins heightens the cardiovascular risk.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalJournal of Hazardous Materials
StatePublished - 30 Dec 2011


  • Cardiovascular disease
  • Framingham risk score
  • PCDD/Fs


Dive into the research topics of 'Predicting the risk of cardiovascular disease in people exposed to moderate to high levels of dioxin'. Together they form a unique fingerprint.

Cite this