Predicting the Origin of Ventricular Arrhythmia Using Acoustic Cardiography

Chin Yu Lin, Shih Lin Chang*, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Tze Fan Chao, Fa Po Chung, Ta Chuan Tuan, Jo Nan Liao, Yao Ting Chang, Abigail Louise D. Te, Shinya Yamada, Hao Min Cheng, Shih Hsien Sung, Ling Kuo, Hsing Yuan Li, Ting Yung Chang, Hoang Quang Minh, Simon Salim, Ting Chung HuangShih Ann Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


This study aimed to examine the relationship between measurements related to heart sounds and the origin of ventricular arrhythmia. We retrospectively evaluated 45 patients undergoing catheter ablation with contemporaneous digital acoustic cardiography of the first heart sound (S1) and the second heart sound (S2). The patients with baseline wide QRS morphology (>120 ms or aberrant conduction), heart failure, valvular heart disease, chronic pulmonary disease, and obesity were excluded. Ventricular arrhythmias from the left ventricle had an increased S1 complexity score and S1 duration in comparison to adjacent sinus beats. On the other hand, ventricular arrhythmia from right ventricle had decreased S1 complexity score and S1 duration in comparison to adjacent sinus beats. The difference of S1 (ΔS1) parameters between premature ventricular complex and sinus beat was significantly smaller in right ventricular arrhythmia group compared with and left ventricular arrhythmia group. For predicting the origin of ventricular arrhythmia, the ΔS1 duration provide better predictive accuracy (sensitivity: 100%, specificity: 100%, cutoff value:-1.28 ms) in comparison to ΔS1 complexity score (sensitivity 71.4%, specificity 75.0%, cutoff value:-0.13). The change of S1 complexity and duration determined from acoustic cardiography could accurately predict the ventricular arrhythmia origin.

Original languageEnglish
Article number15490
JournalScientific reports
Issue number1
StatePublished - 1 Dec 2017


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