Predicting factors for atrial fibrillation acute termination during catheter ablation procedures: Implications for catheter ablation strategy and long-term outcome

Li Wei Lo, Ching Tai Tai, Yenn Jiang Lin, Shih Lin Chang, Ameya R. Udyavar, Yu Feng Hu, Kuo Chang Ueng, Wen Chin Tsai, Ta Chun Tuan, Chien Jung Chang, Tsair Kao, Hsuan Ming Tsao, Wanwarang Wongcharoen, Satoshi Higa, Shih Ann Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Background: Termination of atrial fibrillation (AF) can be achieved by catheter ablation. It has been used as one of the procedural endpoints for AF ablation. Objective: The purpose of this study was to investigate the factors that predict AF termination and the association with long-term outcomes. Methods: Eighty-five consecutive AF patients (33 paroxysmal, 52 nonparoxysmal) underwent three-dimensional mapping and catheter ablation. A stepwise ablation approach included circumferential pulmonary vein (PV) isolation and left atrial (LA) linear ablation, followed by LA and right atrial (RA) electrogram-based (complex fractionated atrial electrogram) ablation. Clinical and electrophysiologic characteristics were assessed to evaluate the predictors of acute AF termination. Results: In univariate analysis, a diagnosis of paroxysmal AF, shorter AF history, absence of history of heart failure, smaller LA diameter, longer postablation coronary sinus cycle length, lower LA and RA mean dominant frequencies, lower RA max dominant frequency, and higher LA voltage were related to acute termination of AF during ablation. Multivariate analysis showed that smaller LA diameter and lower preablation mean RA dominant frequency were independent predictors of AF termination. Multivariate analysis also showed that larger LA diameter and the presence of RA non-PV ectopy during the index procedure could predict late recurrence during long-term (13 ± 8 months) follow-up. Conclusion: LA size and RA non-PV drivers are important for acute termination of AF and for long-term success. Careful selection of patients, extensive RA mapping, and LA ablation may enhance long-term ablation efficacy.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalHeart Rhythm
Volume6
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Ablation
  • Atrial fibrillation
  • Left atrium
  • Predictors
  • Termination

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