Pre-clinical tests of an integrated CMOS biomolecular sensor for cardiac diseases diagnosis

Jen Kuang Lee, I. Shun Wang, Chi Hsien Huang, Yih Fan Chen, Nien Tsu Huang, Chih Ting Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Coronary artery disease and its related complications pose great threats to human health. In this work, we aim to clinically evaluate a CMOS field-effect biomolecular sensor for cardiac biomarkers, cardiac-specific troponin-I (cTnI), N-terminal prohormone brain natriuretic peptide (NT-proBNP), and interleukin-6 (IL-6). The CMOS biosensor is implemented via a standard commercialized 0.35 _m CMOS process. To validate the sensing characteristics, in buffer conditions, the developed CMOS biosensor has identified the detection limits of IL-6, cTnI, and NT-proBNP as being 45 pM, 32 pM, and 32 pM, respectively. In clinical serum conditions, furthermore, the developed CMOS biosensor performs a good correlation with an enzyme-linked immuno-sorbent assay (ELISA) obtained from a hospital central laboratory. Based on this work, the CMOS field-effect biosensor poses good potential for accomplishing the needs of a point-of-care testing (POCT) system for heart disease diagnosis.

Original languageEnglish
Article number2733
JournalSensors (Switzerland)
Volume17
Issue number12
DOIs
StatePublished - Dec 2017

Keywords

  • CMOS biosensor
  • Field-effect biosensor
  • Heart disease
  • Interleukin-6
  • N-terminal prohormone brain natriuretic peptide
  • Troponin-I

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