Post-recurrence survival in completely resected stage i non-small cell lung cancer with local recurrence

J. J. Hung, W. H. Hsu, C. C. Hsieh, B. S. Huang, M. H. Huang, J. S. Liu, Y. C. Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Objective: Resection is the best treatment for patients with stage I non-small cell lung cancer (NSCLC), Patterns of disease recurrence after complete resection in stage I NSCLC have not been well demonstrated, The aim of this study was to evaluate the prognostic predictors of post-recurrence survival in patients with resected stage I NSCLC with local recurrence. Methods: The clinicopathological characteristics of 123 patients with local recurrence after complete resection of stage I NSCLC in Taipei Veterans General Hospital between 1980 and 2000 were retrospectively reviewed. Post-recurrence survival and their predictors were analysed. Results: The patterns of local recurrence included local only in 74 (60.2%) and both local and distant in 49 (39.8%) patients, The 1 and 2 year post-recurrence survival rates for the 74 patients with local only recurrence were 48.7% and 17.6%, respectively. Tumour size (p = 0.033) and treatment for initial recurrence (p<0.001) were significant predictors for post-recurrence survival in 74 patients with local only recurrence in univariate analyses, The hazard of death was greater in patients with larger tumour size. Treatment for initial recurrence (p = 0.001) was still a significant prognostic indicator in multivariate analyses. Patients who underwent reoperation after local recurrence survived longer than those who received chemotherapy and/or radiotherapy and those that received no treatment. Conclusions: Treatment for initial recurrence is a prognostic predictor for post-recurrence survival in resected stage I NSCLC with local recurrence, Complete surgical resection should be considered in selected candidates with resectable local recurrent disease.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalThorax
Volume64
Issue number3
DOIs
StatePublished - Mar 2009

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