Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias

Wei Tso Chen; Cheng Hung Li; Yu Hui Chou; Wei Lun Lin; Yenn Jiang Lin; Shih Lin Chang; Yu Feng Hu; Fa Po Chung; Jo Nan Liao; Ta Chuan Tuan; Tze Fan Chao; Chin Yu Lin; Ting Yung Chang; Ling Kuo; Chih Min Liu; Shin Huei Liu; Wen Han Cheng; Ton Nukhank An; Ahmed Moustafa Moustafa Elimam; Chhay Chheng; Thien Chuong Khac Nguyen; Ibrahim Ahliah; Ming Ren Kuo; Pei Heng Kao; Shih Ann Chen; Li Wei Lo

doi:10.1016/j.jjcc.2022.11.003

Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias

Wei Tso Chen, Cheng Hung Li, Yu Hui Chou, Wei Lun Lin, Yenn Jiang Lin, Shih Lin Chang, Yu Feng Hu, Fa Po Chung, Jo Nan Liao, Ta Chuan Tuan, Tze Fan Chao, Chin Yu Lin, Ting Yung Chang, Ling Kuo, Chih Min Liu, Shin Huei Liu, Wen Han Cheng, Ton Nukhank An, Ahmed Moustafa Moustafa Elimam, Chhay ChhengThien Chuong Khac Nguyen, Ibrahim Ahliah, Ming Ren Kuo, Pei Heng Kao, Shih Ann Chen^*, Li Wei Lo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: The neuromodulation effect after ventricular arrhythmia (VA) ablation is unclear. The study aimed to investigate skin sympathetic nerve activity (SKNA) changes in patients receiving catheter ablations for idiopathic VA. Methods: Of 43 patients with drug-refractory symptomatic VA receiving ablation, SKNA was continuously recorded for 10 min during resting from electrocardiogram lead I configuration and bipolar electrodes on the right arm 1 day before and 1 day after ablation. Results: Twenty-two patients with acute procedure success and no recurrence during follow-ups were classified as sustained success group (group 1). Other 21 patients were classified as failed ablation group (group 2). Baseline SKNA showed no significant difference between the two groups. Post-ablation SKNA in group 2 was significantly higher than in group 1. In patients with ablation involved right ventricular outflow tract (RVOT), the post-ablation SKNA was also significantly higher in group 2. In contrast, there was no difference in post-ablation SKNA between groups in patients receiving non-RVOT ablation. Conclusion: The neuromodulation response after RVOT ablation may correspond to the sympathetic nerve distribution at RVOT. Augmentation of sympathetic activity after VA ablation indicates an unsuccessful VA suppression, especially in patients receiving ablation of RVOT VA.

Original language	English
Pages (from-to)	434-440
Number of pages	7
Journal	Journal of Cardiology
Volume	81
Issue number	5
DOIs	https://doi.org/10.1016/j.jjcc.2022.11.003
State	Published - May 2023

Keywords

Right ventricular outflow tract
Skin sympathetic nerve activity
Ventricular premature complexes

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10.1016/j.jjcc.2022.11.003

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Chen, W. T., Li, C. H., Chou, Y. H., Lin, W. L., Lin, Y. J., Chang, S. L., Hu, Y. F., Chung, F. P., Liao, J. N., Tuan, T. C., Chao, T. F., Lin, C. Y., Chang, T. Y., Kuo, L., Liu, C. M., Liu, S. H., Cheng, W. H., An, T. N., Elimam, A. M. M., ... Lo, L. W. (2023). Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias. Journal of Cardiology, 81(5), 434-440. https://doi.org/10.1016/j.jjcc.2022.11.003

@article{4c63501980c34afe854036e0e204e18f,

title = "Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias",

abstract = "Background: The neuromodulation effect after ventricular arrhythmia (VA) ablation is unclear. The study aimed to investigate skin sympathetic nerve activity (SKNA) changes in patients receiving catheter ablations for idiopathic VA. Methods: Of 43 patients with drug-refractory symptomatic VA receiving ablation, SKNA was continuously recorded for 10 min during resting from electrocardiogram lead I configuration and bipolar electrodes on the right arm 1 day before and 1 day after ablation. Results: Twenty-two patients with acute procedure success and no recurrence during follow-ups were classified as sustained success group (group 1). Other 21 patients were classified as failed ablation group (group 2). Baseline SKNA showed no significant difference between the two groups. Post-ablation SKNA in group 2 was significantly higher than in group 1. In patients with ablation involved right ventricular outflow tract (RVOT), the post-ablation SKNA was also significantly higher in group 2. In contrast, there was no difference in post-ablation SKNA between groups in patients receiving non-RVOT ablation. Conclusion: The neuromodulation response after RVOT ablation may correspond to the sympathetic nerve distribution at RVOT. Augmentation of sympathetic activity after VA ablation indicates an unsuccessful VA suppression, especially in patients receiving ablation of RVOT VA.",

keywords = "Right ventricular outflow tract, Skin sympathetic nerve activity, Ventricular premature complexes",

author = "Chen, {Wei Tso} and Li, {Cheng Hung} and Chou, {Yu Hui} and Lin, {Wei Lun} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Hu, {Yu Feng} and Chung, {Fa Po} and Liao, {Jo Nan} and Tuan, {Ta Chuan} and Chao, {Tze Fan} and Lin, {Chin Yu} and Chang, {Ting Yung} and Ling Kuo and Liu, {Chih Min} and Liu, {Shin Huei} and Cheng, {Wen Han} and An, {Ton Nukhank} and Elimam, {Ahmed Moustafa Moustafa} and Chhay Chheng and Nguyen, {Thien Chuong Khac} and Ibrahim Ahliah and Kuo, {Ming Ren} and Kao, {Pei Heng} and Chen, {Shih Ann} and Lo, {Li Wei}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2023",

month = may,

doi = "10.1016/j.jjcc.2022.11.003",

language = "English",

volume = "81",

pages = "434--440",

journal = "Journal of Cardiology",

issn = "0914-5087",

publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",

number = "5",

}

Chen, WT, Li, CH, Chou, YH, Lin, WL, Lin, YJ, Chang, SL , Hu, YF, Chung, FP, Liao, JN, Tuan, TC, Chao, TF, Lin, CY, Chang, TY, Kuo, L, Liu, CM, Liu, SH, Cheng, WH, An, TN, Elimam, AMM, Chheng, C, Nguyen, TCK, Ahliah, I, Kuo, MR, Kao, PH, Chen, SA & Lo, LW 2023, 'Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias', Journal of Cardiology, vol. 81, no. 5, pp. 434-440. https://doi.org/10.1016/j.jjcc.2022.11.003

TY - JOUR

T1 - Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias

AU - Chen, Wei Tso

AU - Li, Cheng Hung

AU - Chou, Yu Hui

AU - Lin, Wei Lun

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Hu, Yu Feng

AU - Chung, Fa Po

AU - Liao, Jo Nan

AU - Tuan, Ta Chuan

AU - Chao, Tze Fan

AU - Lin, Chin Yu

AU - Chang, Ting Yung

AU - Kuo, Ling

AU - Liu, Chih Min

AU - Liu, Shin Huei

AU - Cheng, Wen Han

AU - An, Ton Nukhank

AU - Elimam, Ahmed Moustafa Moustafa

AU - Chheng, Chhay

AU - Nguyen, Thien Chuong Khac

AU - Ahliah, Ibrahim

AU - Kuo, Ming Ren

AU - Kao, Pei Heng

AU - Chen, Shih Ann

AU - Lo, Li Wei

PY - 2023/5

Y1 - 2023/5

N2 - Background: The neuromodulation effect after ventricular arrhythmia (VA) ablation is unclear. The study aimed to investigate skin sympathetic nerve activity (SKNA) changes in patients receiving catheter ablations for idiopathic VA. Methods: Of 43 patients with drug-refractory symptomatic VA receiving ablation, SKNA was continuously recorded for 10 min during resting from electrocardiogram lead I configuration and bipolar electrodes on the right arm 1 day before and 1 day after ablation. Results: Twenty-two patients with acute procedure success and no recurrence during follow-ups were classified as sustained success group (group 1). Other 21 patients were classified as failed ablation group (group 2). Baseline SKNA showed no significant difference between the two groups. Post-ablation SKNA in group 2 was significantly higher than in group 1. In patients with ablation involved right ventricular outflow tract (RVOT), the post-ablation SKNA was also significantly higher in group 2. In contrast, there was no difference in post-ablation SKNA between groups in patients receiving non-RVOT ablation. Conclusion: The neuromodulation response after RVOT ablation may correspond to the sympathetic nerve distribution at RVOT. Augmentation of sympathetic activity after VA ablation indicates an unsuccessful VA suppression, especially in patients receiving ablation of RVOT VA.

AB - Background: The neuromodulation effect after ventricular arrhythmia (VA) ablation is unclear. The study aimed to investigate skin sympathetic nerve activity (SKNA) changes in patients receiving catheter ablations for idiopathic VA. Methods: Of 43 patients with drug-refractory symptomatic VA receiving ablation, SKNA was continuously recorded for 10 min during resting from electrocardiogram lead I configuration and bipolar electrodes on the right arm 1 day before and 1 day after ablation. Results: Twenty-two patients with acute procedure success and no recurrence during follow-ups were classified as sustained success group (group 1). Other 21 patients were classified as failed ablation group (group 2). Baseline SKNA showed no significant difference between the two groups. Post-ablation SKNA in group 2 was significantly higher than in group 1. In patients with ablation involved right ventricular outflow tract (RVOT), the post-ablation SKNA was also significantly higher in group 2. In contrast, there was no difference in post-ablation SKNA between groups in patients receiving non-RVOT ablation. Conclusion: The neuromodulation response after RVOT ablation may correspond to the sympathetic nerve distribution at RVOT. Augmentation of sympathetic activity after VA ablation indicates an unsuccessful VA suppression, especially in patients receiving ablation of RVOT VA.

KW - Right ventricular outflow tract

KW - Skin sympathetic nerve activity

KW - Ventricular premature complexes

UR - http://www.scopus.com/inward/record.url?scp=85142439284&partnerID=8YFLogxK

U2 - 10.1016/j.jjcc.2022.11.003

DO - 10.1016/j.jjcc.2022.11.003

M3 - Article

C2 - 36372323

AN - SCOPUS:85142439284

SN - 0914-5087

VL - 81

SP - 434

EP - 440

JO - Journal of Cardiology

JF - Journal of Cardiology

IS - 5

ER -

Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias

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