Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias

Wei Tso Chen, Cheng Hung Li, Yu Hui Chou, Wei Lun Lin, Yenn Jiang Lin, Shih Lin Chang, Yu Feng Hu, Fa Po Chung, Jo Nan Liao, Ta Chuan Tuan, Tze Fan Chao, Chin Yu Lin, Ting Yung Chang, Ling Kuo, Chih Min Liu, Shin Huei Liu, Wen Han Cheng, Ton Nukhank An, Ahmed Moustafa Moustafa Elimam, Chhay ChhengThien Chuong Khac Nguyen, Ibrahim Ahliah, Ming Ren Kuo, Pei Heng Kao, Shih Ann Chen*, Li Wei Lo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: The neuromodulation effect after ventricular arrhythmia (VA) ablation is unclear. The study aimed to investigate skin sympathetic nerve activity (SKNA) changes in patients receiving catheter ablations for idiopathic VA. Methods: Of 43 patients with drug-refractory symptomatic VA receiving ablation, SKNA was continuously recorded for 10 min during resting from electrocardiogram lead I configuration and bipolar electrodes on the right arm 1 day before and 1 day after ablation. Results: Twenty-two patients with acute procedure success and no recurrence during follow-ups were classified as sustained success group (group 1). Other 21 patients were classified as failed ablation group (group 2). Baseline SKNA showed no significant difference between the two groups. Post-ablation SKNA in group 2 was significantly higher than in group 1. In patients with ablation involved right ventricular outflow tract (RVOT), the post-ablation SKNA was also significantly higher in group 2. In contrast, there was no difference in post-ablation SKNA between groups in patients receiving non-RVOT ablation. Conclusion: The neuromodulation response after RVOT ablation may correspond to the sympathetic nerve distribution at RVOT. Augmentation of sympathetic activity after VA ablation indicates an unsuccessful VA suppression, especially in patients receiving ablation of RVOT VA.

Original languageEnglish
Pages (from-to)434-440
Number of pages7
JournalJournal of Cardiology
Issue number5
StatePublished - May 2023


  • Right ventricular outflow tract
  • Skin sympathetic nerve activity
  • Ventricular premature complexes


Dive into the research topics of 'Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias'. Together they form a unique fingerprint.

Cite this