Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers

K. W. Chang; T. C. Lee; W. I. Yeh; M. Y. Chung; C. J. Liu; L. Y. Chi; S. C. Lin

doi:10.1038/sj.bjc.6602186

Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers

K. W. Chang, T. C. Lee, W. I. Yeh, M. Y. Chung, C. J. Liu, L. Y. Chi, S. C. Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Areca (betel) chewing is associated with the high incidence of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) in Asians. Heme oxygenase-1 (HO-1), encoding an oxidative response protein, plays protective roles in cells. A (GT)_n microsatellite repeat in HO-1 promoter shows polymorphisms and modulates the level of gene transcription. We examined allelotypic frequencies of (GT)_n repeats in 83 controls, 147 OSCC and 71 OSF. All subjects were male areca chewers. Logistic regression was used to adjust the age confounding for odds ratio (OR). (GT)_n repeat polymorphism was classified into short (S), medium (M) and long (L) alleles. The adjusted OR in OSCC subjects carrying L allelotype relative to S allelotype was 1.75. Buccal squamous cell carcinoma (BSCC) is the most common OSCC subset in areca chewers. L allelotype implied the risk of BSCC with adjusted OR of 2.05, whereas M allelotype appeared protective for non-BSCC with adjusted OR of 0.49. Our findings indicated that longer (GT)_n repeat allele in HO-1 promoter is associated with the risks of areca-related OSCC, while the shorter (GT)_n repeat allele may have protective effects for OSCC.

Original language	English
Pages (from-to)	1551-1555
Number of pages	5
Journal	British Journal of Cancer
Volume	91
Issue number	8
DOIs	https://doi.org/10.1038/sj.bjc.6602186
State	Published - 18 Oct 2004

Keywords

Gene polymorphism
HO-1
Mouth
Neoplasm
Oral submucous fibrosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/sj.bjc.6602186

Cite this

@article{91f3bf26980f4cdfb1408c41cafba6c8,

title = "Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers",

abstract = "Areca (betel) chewing is associated with the high incidence of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) in Asians. Heme oxygenase-1 (HO-1), encoding an oxidative response protein, plays protective roles in cells. A (GT)n microsatellite repeat in HO-1 promoter shows polymorphisms and modulates the level of gene transcription. We examined allelotypic frequencies of (GT)n repeats in 83 controls, 147 OSCC and 71 OSF. All subjects were male areca chewers. Logistic regression was used to adjust the age confounding for odds ratio (OR). (GT)n repeat polymorphism was classified into short (S), medium (M) and long (L) alleles. The adjusted OR in OSCC subjects carrying L allelotype relative to S allelotype was 1.75. Buccal squamous cell carcinoma (BSCC) is the most common OSCC subset in areca chewers. L allelotype implied the risk of BSCC with adjusted OR of 2.05, whereas M allelotype appeared protective for non-BSCC with adjusted OR of 0.49. Our findings indicated that longer (GT)n repeat allele in HO-1 promoter is associated with the risks of areca-related OSCC, while the shorter (GT)n repeat allele may have protective effects for OSCC.",

keywords = "Gene polymorphism, HO-1, Mouth, Neoplasm, Oral submucous fibrosis",

author = "Chang, {K. W.} and Lee, {T. C.} and Yeh, {W. I.} and Chung, {M. Y.} and Liu, {C. J.} and Chi, {L. Y.} and Lin, {S. C.}",

note = "Funding Information: We thank Ms Bin-Lin Chen for her help. This study was supported by the Mackay-Yang Ming Research Project MMHYM 93-N-010-013 and National Research Program for Genome Medicine 91GMP004-3.",

year = "2004",

month = oct,

day = "18",

doi = "10.1038/sj.bjc.6602186",

language = "English",

volume = "91",

pages = "1551--1555",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "8",

}

TY - JOUR

T1 - Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers

AU - Chang, K. W.

AU - Lee, T. C.

AU - Yeh, W. I.

AU - Chung, M. Y.

AU - Liu, C. J.

AU - Chi, L. Y.

AU - Lin, S. C.

N1 - Funding Information: We thank Ms Bin-Lin Chen for her help. This study was supported by the Mackay-Yang Ming Research Project MMHYM 93-N-010-013 and National Research Program for Genome Medicine 91GMP004-3.

PY - 2004/10/18

Y1 - 2004/10/18

N2 - Areca (betel) chewing is associated with the high incidence of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) in Asians. Heme oxygenase-1 (HO-1), encoding an oxidative response protein, plays protective roles in cells. A (GT)n microsatellite repeat in HO-1 promoter shows polymorphisms and modulates the level of gene transcription. We examined allelotypic frequencies of (GT)n repeats in 83 controls, 147 OSCC and 71 OSF. All subjects were male areca chewers. Logistic regression was used to adjust the age confounding for odds ratio (OR). (GT)n repeat polymorphism was classified into short (S), medium (M) and long (L) alleles. The adjusted OR in OSCC subjects carrying L allelotype relative to S allelotype was 1.75. Buccal squamous cell carcinoma (BSCC) is the most common OSCC subset in areca chewers. L allelotype implied the risk of BSCC with adjusted OR of 2.05, whereas M allelotype appeared protective for non-BSCC with adjusted OR of 0.49. Our findings indicated that longer (GT)n repeat allele in HO-1 promoter is associated with the risks of areca-related OSCC, while the shorter (GT)n repeat allele may have protective effects for OSCC.

AB - Areca (betel) chewing is associated with the high incidence of oral squamous cell carcinoma (OSCC) and oral submucous fibrosis (OSF) in Asians. Heme oxygenase-1 (HO-1), encoding an oxidative response protein, plays protective roles in cells. A (GT)n microsatellite repeat in HO-1 promoter shows polymorphisms and modulates the level of gene transcription. We examined allelotypic frequencies of (GT)n repeats in 83 controls, 147 OSCC and 71 OSF. All subjects were male areca chewers. Logistic regression was used to adjust the age confounding for odds ratio (OR). (GT)n repeat polymorphism was classified into short (S), medium (M) and long (L) alleles. The adjusted OR in OSCC subjects carrying L allelotype relative to S allelotype was 1.75. Buccal squamous cell carcinoma (BSCC) is the most common OSCC subset in areca chewers. L allelotype implied the risk of BSCC with adjusted OR of 2.05, whereas M allelotype appeared protective for non-BSCC with adjusted OR of 0.49. Our findings indicated that longer (GT)n repeat allele in HO-1 promoter is associated with the risks of areca-related OSCC, while the shorter (GT)n repeat allele may have protective effects for OSCC.

KW - Gene polymorphism

KW - HO-1

KW - Mouth

KW - Neoplasm

KW - Oral submucous fibrosis

UR - http://www.scopus.com/inward/record.url?scp=7944222236&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6602186

DO - 10.1038/sj.bjc.6602186

M3 - Article

C2 - 15365571

AN - SCOPUS:7944222236

SN - 0007-0920

VL - 91

SP - 1551

EP - 1555

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 8

ER -

Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this