Poly(lactic-co-glycolic acid) and functional hydrogels for drug delivery applications

Hongyan He, L. James Lee

Research output: Contribution to conferencePaperpeer-review

7 Scopus citations

Abstract

Biodegradable polyesters like poly(lactide-coglycolide acid) (PLGA) and pH-sensitive hydrogels have been used increasingly for various medical and biological applications. The present work focused on the use of these functional polymers to design an assembled drug delivery system (DDS) that could integrate multiple functions in a single device and achieve different release patterns. For PLGA, The major concerns are the poor hydrophilicity, accumulated acidity during degradation, and bulk erosion characteristics. In this study, poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) tri-block copolymer and a nano-clay Cloisite® 30B were utilized as modifiers to control the degradation behavior and hydrophilicity of PLGA. For comparison, a block copolymer, poly(lactic acid)/ poly(ethylene glycol) (PLA-co-PEG) was synthesized. A pH-sensitive hydrogel together with a poly(hydroxyethyl methacrylate) (HEMA) was used as a gate to control drug release. By using this bilayered self-folding design, the drug protection and self-regulated oscillatory release were demonstrated.

Original languageEnglish
Pages3356-3360
Number of pages5
StatePublished - May 2004
EventANTEC 2004 - Annual Technical Conference Proceedings - Chicago, IL., United States
Duration: 16 May 200420 May 2004

Conference

ConferenceANTEC 2004 - Annual Technical Conference Proceedings
Country/TerritoryUnited States
CityChicago, IL.
Period16/05/0420/05/04

Keywords

  • Biodegradable polyester
  • Hydrogels
  • Poly(lactic-co-glycolic acid)
  • Self-folding

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