Polarization-sensitive optical coherence tomography for imaging human atherosclerosis

Wen Chuan Kuo*, Nai Kuan Chou, Chien Chou, Chih Ming Lai, Huan Jang Huang, Shoei Shen Wang, Jeou Jong Shyu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT with image contrast enhancement, which is based on its ability to detect phase retardation and the fast-axis angle. Both PS-OCT images and histopathology have demonstrated similar features that allowed differentiation of atherosclerotic structures (i.e., plaques) from normal tissue. Moreover, the picrosirius polarization method was used to confirm PS-OCT assessment of collagen in the fibrous cap of atherosclerotic plaques, and high-frequency (40 MHz) ultrasound images were used to identify calcium in the vessel wall. Our preliminary ex vivo investigation of human aortic specimens indicated that PS-OCT might help to identify atherosclerotic lesions.

Original languageEnglish
Pages (from-to)2520-2527
Number of pages8
JournalApplied Optics
Issue number13
StatePublished - 1 May 2007


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