TY - JOUR
T1 - PM2.5 air pollution contributes to the burden of frailty
AU - Lee, Wei Ju
AU - Liu, Ching Yi
AU - Peng, Li Ning
AU - Lin, Chi Hung
AU - Lin, Hui Ping
AU - Chen, Liang Kung
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM2.5 is associated with frailty. This cross-sectional study involved 20,606 community-dwelling participants aged ≥ 65 years, residing in New Taipei City, Taiwan. Analytic data included phenotypic frailty, disease burden by Charlson Comorbidity Index (CCI), urban or rural residence, and household income. PM2.5 exposure was calculated from air quality monitoring records, with low exposure defined as the lowest quartile of the study population. 1,080 frail participants (5.2%) were older, predominantly female, had more comorbidities, lived rurally, and had low PM2.5 exposure (all p < 0.001). In multinomial logistic regression analyses, the likelihood of high PM2.5 exposure was higher in prefrail (OR 1.4, 95% CI 1.3–1.5) and frail adults (OR 1.5, 95% CI 1.2–1.9) than in robust individuals, with stronger associations in those who were male (frail: OR 2.1, 95% CI 1.5–3.1; prefrail: OR 2.2, 95% CI 1.9–2.6), ≥ 75 years old (frail: OR 1.8, 95% CI 1.3–2.4; prefrail: OR 1.5, 95% CI 1.3–1.8), non-smokers (frail: OR 1.6, 95% CI 1.3–2.0; prefrail: OR 1.4, 95% CI 1.2–1.5), had CCI ≥ 2 (frail: OR 5.1, 95% CI 2.1–12.6; prefrail: OR 2.1, 95% CI 1.2–3.8), and with low household income (frail: OR 4.0, 95% CI 2.8–5.8; prefrail: OR 2.7, 95% CI 2.2–3.3). This study revealed a significant association between PM2.5 exposure and frailty, with a stronger effect in vulnerable groups.
AB - Frailty is common among older people and results in adverse health outcomes. We investigated whether exposure to PM2.5 is associated with frailty. This cross-sectional study involved 20,606 community-dwelling participants aged ≥ 65 years, residing in New Taipei City, Taiwan. Analytic data included phenotypic frailty, disease burden by Charlson Comorbidity Index (CCI), urban or rural residence, and household income. PM2.5 exposure was calculated from air quality monitoring records, with low exposure defined as the lowest quartile of the study population. 1,080 frail participants (5.2%) were older, predominantly female, had more comorbidities, lived rurally, and had low PM2.5 exposure (all p < 0.001). In multinomial logistic regression analyses, the likelihood of high PM2.5 exposure was higher in prefrail (OR 1.4, 95% CI 1.3–1.5) and frail adults (OR 1.5, 95% CI 1.2–1.9) than in robust individuals, with stronger associations in those who were male (frail: OR 2.1, 95% CI 1.5–3.1; prefrail: OR 2.2, 95% CI 1.9–2.6), ≥ 75 years old (frail: OR 1.8, 95% CI 1.3–2.4; prefrail: OR 1.5, 95% CI 1.3–1.8), non-smokers (frail: OR 1.6, 95% CI 1.3–2.0; prefrail: OR 1.4, 95% CI 1.2–1.5), had CCI ≥ 2 (frail: OR 5.1, 95% CI 2.1–12.6; prefrail: OR 2.1, 95% CI 1.2–3.8), and with low household income (frail: OR 4.0, 95% CI 2.8–5.8; prefrail: OR 2.7, 95% CI 2.2–3.3). This study revealed a significant association between PM2.5 exposure and frailty, with a stronger effect in vulnerable groups.
UR - http://www.scopus.com/inward/record.url?scp=85090126568&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-71408-w
DO - 10.1038/s41598-020-71408-w
M3 - Article
C2 - 32879354
AN - SCOPUS:85090126568
SN - 2045-2322
VL - 10
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 14478
ER -
