Plasmonic agarose gel droplets for SERS detection of molecules in complex fluids and cell culture medium

Yun Chu Chen, Kuan Ying Chen, Yih Fan Chen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this study we develop a gel-based SERS method that can be used to detect molecules in complex fluids such as cell culture medium by using gels to separate small target molecules from cells and large molecules such as proteins. We demonstrate the capability of our method by detecting adenine in protein-rich solutions and cell culture medium with E. coli without any sample pretreatment before measurement. We also show that we can detect 1 nM adenine in solution that contains 1% BSA and 1% casein.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages975-977
Number of pages3
ISBN (Electronic)9781510897571
StatePublished - Nov 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan
Duration: 11 Nov 201815 Nov 2018

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume2

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Country/TerritoryTaiwan
CityKaohsiung
Period11/11/1815/11/18

Keywords

  • Adenine
  • Droplet
  • Gel
  • Surface-enhanced Raman spectroscopy (SERS)

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