Planned Short-Course Radiation (scRT) is Superior to Upfront Concurrent Chemoradiation (CCRT) in Treating Metastatic Rectal Cancer

Hao Wei Teng; Jen Kou Lin; Tzu Chen Lin; Wei Shone Chen; Jeng Kai Jiang; Shung Haur Yang; Huann Sheng Wang; Shih Ching Chang; Yuan Tzu Lan; Chun chi Lin; Hung Hsin Lin; Sheng Chieh Huang

doi:10.1007/s11605-019-04256-3

Planned Short-Course Radiation (scRT) is Superior to Upfront Concurrent Chemoradiation (CCRT) in Treating Metastatic Rectal Cancer

Hao Wei Teng^*, Jen Kou Lin, Tzu Chen Lin, Wei Shone Chen, Jeng Kai Jiang, Shung Haur Yang, Huann Sheng Wang, Shih Ching Chang, Yuan Tzu Lan, Chun chi Lin, Hung Hsin Lin, Sheng Chieh Huang

^*Corresponding author for this work

Department of Surgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background or Purpose: To compare the cost-performance between planned short-course radiation and upfront concurrent chemoradiation on metastatic rectal cancer. Methods: A total of 75 patients with metastatic rectal cancer who underwent planned short-course radiation or upfront concurrent chemoradiation were enrolled. The Kaplan-Meier method was used to compute the survival rates. The χ² test was used to compare baseline characteristics. The Cox proportional hazards model was applied to determine the prognostic influence of clinicopathological factors. Results: The planned short-course radiation is superior to upfront concurrent chemoradiation in overall survival for the patients with metastatic rectal cancer (34.8 vs. 20.2 months, P = 0.010). The planned short-course radiation was an independent prognostic factor (P = 0.009, HR (95% CI) = 0.319(0.135–0.752)). The efficacy of radiation on downstaging was similar between planned short-course radiation and upfront concurrent chemoradiation. The total cost of concurrent chemoradiation is 4.52-fold more expensive than that of short-course radiation (340,142 vs. 75,106 NT dollars, respectively). Conclusions: Based on the impressive cost-performance of planned short-course radiation compared with upfront concurrent chemoradiation (better OS, modest downstaging and lower cost), planned short-course radiation should be the preferred radiation approach for managing metastatic rectal cancer.

Original language	English
Pages (from-to)	1092-1100
Number of pages	9
Journal	Journal of Gastrointestinal Surgery
Volume	24
Issue number	5
DOIs	https://doi.org/10.1007/s11605-019-04256-3
State	Published - 1 May 2020

Keywords

Cost
Metastasectomy
Metastatic rectal cancer
Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11605-019-04256-3

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Teng, H. W., Lin, J. K., Lin, T. C., Chen, W. S., Jiang, J. K., Yang, S. H., Wang, H. S., Chang, S. C., Lan, Y. T., Lin, C. C., Lin, H. H., & Huang, S. C. (2020). Planned Short-Course Radiation (scRT) is Superior to Upfront Concurrent Chemoradiation (CCRT) in Treating Metastatic Rectal Cancer. Journal of Gastrointestinal Surgery, 24(5), 1092-1100. https://doi.org/10.1007/s11605-019-04256-3

@article{ba1212b8f6ff4b6db57bbcd167ea5872,

title = "Planned Short-Course Radiation (scRT) is Superior to Upfront Concurrent Chemoradiation (CCRT) in Treating Metastatic Rectal Cancer",

abstract = "Background or Purpose: To compare the cost-performance between planned short-course radiation and upfront concurrent chemoradiation on metastatic rectal cancer. Methods: A total of 75 patients with metastatic rectal cancer who underwent planned short-course radiation or upfront concurrent chemoradiation were enrolled. The Kaplan-Meier method was used to compute the survival rates. The χ2 test was used to compare baseline characteristics. The Cox proportional hazards model was applied to determine the prognostic influence of clinicopathological factors. Results: The planned short-course radiation is superior to upfront concurrent chemoradiation in overall survival for the patients with metastatic rectal cancer (34.8 vs. 20.2 months, P = 0.010). The planned short-course radiation was an independent prognostic factor (P = 0.009, HR (95% CI) = 0.319(0.135–0.752)). The efficacy of radiation on downstaging was similar between planned short-course radiation and upfront concurrent chemoradiation. The total cost of concurrent chemoradiation is 4.52-fold more expensive than that of short-course radiation (340,142 vs. 75,106 NT dollars, respectively). Conclusions: Based on the impressive cost-performance of planned short-course radiation compared with upfront concurrent chemoradiation (better OS, modest downstaging and lower cost), planned short-course radiation should be the preferred radiation approach for managing metastatic rectal cancer.",

keywords = "Cost, Metastasectomy, Metastatic rectal cancer, Radiation",

author = "Teng, {Hao Wei} and Lin, {Jen Kou} and Lin, {Tzu Chen} and Chen, {Wei Shone} and Jiang, {Jeng Kai} and Yang, {Shung Haur} and Wang, {Huann Sheng} and Chang, {Shih Ching} and Lan, {Yuan Tzu} and Lin, {Chun chi} and Lin, {Hung Hsin} and Huang, {Sheng Chieh}",

note = "Publisher Copyright: {\textcopyright} 2019, The Society for Surgery of the Alimentary Tract.",

year = "2020",

month = may,

day = "1",

doi = "10.1007/s11605-019-04256-3",

language = "English",

volume = "24",

pages = "1092--1100",

journal = "Journal of Gastrointestinal Surgery",

issn = "1091-255X",

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T1 - Planned Short-Course Radiation (scRT) is Superior to Upfront Concurrent Chemoradiation (CCRT) in Treating Metastatic Rectal Cancer

AU - Teng, Hao Wei

AU - Lin, Jen Kou

AU - Lin, Tzu Chen

AU - Chen, Wei Shone

AU - Jiang, Jeng Kai

AU - Yang, Shung Haur

AU - Wang, Huann Sheng

AU - Chang, Shih Ching

AU - Lan, Yuan Tzu

AU - Lin, Chun chi

AU - Lin, Hung Hsin

AU - Huang, Sheng Chieh

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Background or Purpose: To compare the cost-performance between planned short-course radiation and upfront concurrent chemoradiation on metastatic rectal cancer. Methods: A total of 75 patients with metastatic rectal cancer who underwent planned short-course radiation or upfront concurrent chemoradiation were enrolled. The Kaplan-Meier method was used to compute the survival rates. The χ2 test was used to compare baseline characteristics. The Cox proportional hazards model was applied to determine the prognostic influence of clinicopathological factors. Results: The planned short-course radiation is superior to upfront concurrent chemoradiation in overall survival for the patients with metastatic rectal cancer (34.8 vs. 20.2 months, P = 0.010). The planned short-course radiation was an independent prognostic factor (P = 0.009, HR (95% CI) = 0.319(0.135–0.752)). The efficacy of radiation on downstaging was similar between planned short-course radiation and upfront concurrent chemoradiation. The total cost of concurrent chemoradiation is 4.52-fold more expensive than that of short-course radiation (340,142 vs. 75,106 NT dollars, respectively). Conclusions: Based on the impressive cost-performance of planned short-course radiation compared with upfront concurrent chemoradiation (better OS, modest downstaging and lower cost), planned short-course radiation should be the preferred radiation approach for managing metastatic rectal cancer.

AB - Background or Purpose: To compare the cost-performance between planned short-course radiation and upfront concurrent chemoradiation on metastatic rectal cancer. Methods: A total of 75 patients with metastatic rectal cancer who underwent planned short-course radiation or upfront concurrent chemoradiation were enrolled. The Kaplan-Meier method was used to compute the survival rates. The χ2 test was used to compare baseline characteristics. The Cox proportional hazards model was applied to determine the prognostic influence of clinicopathological factors. Results: The planned short-course radiation is superior to upfront concurrent chemoradiation in overall survival for the patients with metastatic rectal cancer (34.8 vs. 20.2 months, P = 0.010). The planned short-course radiation was an independent prognostic factor (P = 0.009, HR (95% CI) = 0.319(0.135–0.752)). The efficacy of radiation on downstaging was similar between planned short-course radiation and upfront concurrent chemoradiation. The total cost of concurrent chemoradiation is 4.52-fold more expensive than that of short-course radiation (340,142 vs. 75,106 NT dollars, respectively). Conclusions: Based on the impressive cost-performance of planned short-course radiation compared with upfront concurrent chemoradiation (better OS, modest downstaging and lower cost), planned short-course radiation should be the preferred radiation approach for managing metastatic rectal cancer.

KW - Cost

KW - Metastasectomy

KW - Metastatic rectal cancer

KW - Radiation

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DO - 10.1007/s11605-019-04256-3

M3 - Article

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AN - SCOPUS:85066604170

SN - 1091-255X

VL - 24

SP - 1092

EP - 1100

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

IS - 5

ER -

Planned Short-Course Radiation (scRT) is Superior to Upfront Concurrent Chemoradiation (CCRT) in Treating Metastatic Rectal Cancer

Abstract

Keywords

UN SDGs

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