Photoresponsive protein-graphene-protein hybrid capsules with dual targeted heat-triggered drug delivery approach for enhanced tumor therapy

Shang Hsiu Hu, Ren Hong Fang, Yu Wei Chen, Bang Jie Liao, I. Wei Chen, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

A novel photo-responsive protein-graphene-protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one-component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 μmol g-1) to be later unloaded in a burst-like manner by photo-actuation triggered by near-infrared irradiation. Being biocompatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light-treating area but also widely light-omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local-targeting, on-demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.

Original languageEnglish
Pages (from-to)4144-4155
Number of pages12
JournalAdvanced Functional Materials
Volume24
Issue number26
DOIs
StatePublished - 9 Jul 2014

Keywords

  • double emulsion
  • graphene oxide
  • hyperthermia
  • nanocapsules
  • synergic therapy

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