Photopatternable Biodegradable Aliphatic Polyester with Pendent Benzophenone Groups

Dayong Chen, Chia Chih Chang, Beth Cooper, Angela Silvers, Todd Emrick*, Ryan C. Hayward

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Highly efficient photo-cross-linking reactions enable numerous applications in biomaterials. Here, a photopatternable biodegradable aliphatic polyester with benzophenone pendent groups was synthesized by copper-catalyzed alkyne-azide cycloaddition, affording polyesters that undergo UV-induced cross-linking to yield photopatterned films. Using this material, a self-folding multilayer structure containing polyester/hydrogel bilayer hinges was fabricated. Upon swelling of the hydrogel layer, the construct folds into a triangular tube, which subsequently unfolds due to lipase-catalyzed degradation of the polyester layer. The ability to precisely design such degradation-induced structural changes offers potential for biomaterials and medical applications, such as evolving and responsive 2D and 3D tissue engineering scaffolds.

Original languageEnglish
Pages (from-to)3329-3335
Number of pages7
Issue number10
StatePublished - 12 Oct 2015


Dive into the research topics of 'Photopatternable Biodegradable Aliphatic Polyester with Pendent Benzophenone Groups'. Together they form a unique fingerprint.

Cite this