A Photonic Crystal surface fabricated upon a quartz substrate using nanoimprint lithography has been demonstrated with a signal enhancement factor as high as 7500× for the detection of LD-700 dye spin-coated upon the PC. The detection of spotted Alexa-647 labeled polypeptide on the PC exhibits a 330× SNR improvement. Using dose-response characterization of deposited fluorophore-tagged protein spots, the PCEF surface demonstrated a 140× lower limit of detection compared to a conventional glass substrate.
|Title of host publication||2011 Conference on Lasers and Electro-Optics (CLEO)|
|State||Published - 1 Dec 2011|
|Event||2011 Conference on Lasers and Electro-Optics, CLEO 2011 - Baltimore, MD, United States|
Duration: 1 May 2011 → 6 May 2011
|Name||Conference on Lasers and Electro-Optics|
|Conference||2011 Conference on Lasers and Electro-Optics, CLEO 2011|
|Period||1/05/11 → 6/05/11|