Photoacoustic imaging of tumor vascularization on nude mice

Bson Chiu; Shu Wei Huang; Huihua Kenny Chiang

doi:10.1117/12.700255

Photoacoustic imaging of tumor vascularization on nude mice

Bson Chiu, Shu Wei Huang, Huihua Kenny Chiang^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood on green and near infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days development of tumor after the implant of the tumor cells on the back of nude mice. We observed that the PAI signals increased with the blood vessel developments and the growth of the tumor. This study shows that PAI is suitable for monitoring of the development of blood vessels near the superficial tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in small animals.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
DOIs	https://doi.org/10.1117/12.700255
State	Published - 2007
Event	Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States Duration: 21 Jan 2007 → 24 Jan 2007

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6437
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Country/Territory	United States
City	San Jose, CA
Period	21/01/07 → 24/01/07

Keywords

Angiogenesis
Nude mice
Photoacoustic imaging
Tumor

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10.1117/12.700255

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Chiu, B., Huang, S. W., & Chiang, H. K. (2007). Photoacoustic imaging of tumor vascularization on nude mice. In Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics [64370T] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6437). https://doi.org/10.1117/12.700255

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title = "Photoacoustic imaging of tumor vascularization on nude mice",

abstract = "Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood on green and near infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days development of tumor after the implant of the tumor cells on the back of nude mice. We observed that the PAI signals increased with the blood vessel developments and the growth of the tumor. This study shows that PAI is suitable for monitoring of the development of blood vessels near the superficial tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in small animals.",

keywords = "Angiogenesis, Nude mice, Photoacoustic imaging, Tumor",

author = "Bson Chiu and Huang, {Shu Wei} and Chiang, {Huihua Kenny}",

year = "2007",

doi = "10.1117/12.700255",

language = "English",

isbn = "081946550X",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Photons Plus Ultrasound",

note = "Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics ; Conference date: 21-01-2007 Through 24-01-2007",

}

Chiu, B, Huang, SW & Chiang, HK 2007, Photoacoustic imaging of tumor vascularization on nude mice. in Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics., 64370T, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, San Jose, CA, United States, 21/01/07. https://doi.org/10.1117/12.700255

Photoacoustic imaging of tumor vascularization on nude mice. / Chiu, Bson; Huang, Shu Wei; Chiang, Huihua Kenny.
Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. 2007. 64370T (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6437).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Huang, Shu Wei

AU - Chiang, Huihua Kenny

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N2 - Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood on green and near infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days development of tumor after the implant of the tumor cells on the back of nude mice. We observed that the PAI signals increased with the blood vessel developments and the growth of the tumor. This study shows that PAI is suitable for monitoring of the development of blood vessels near the superficial tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in small animals.

AB - Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast than conventional ultrasound imaging due to the high contrast absorption of blood on green and near infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days development of tumor after the implant of the tumor cells on the back of nude mice. We observed that the PAI signals increased with the blood vessel developments and the growth of the tumor. This study shows that PAI is suitable for monitoring of the development of blood vessels near the superficial tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in small animals.

KW - Angiogenesis

KW - Nude mice

KW - Photoacoustic imaging

KW - Tumor

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T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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Photoacoustic imaging of tumor vascularization on nude mice

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