Phosphine-Mediated [4 + 3] Annulation of Diynoates and 2-Arylidene Indane-1,3-diones: Access of Indeno[1,2- b]oxepin-4-ylidenes and beyond

Sureshbabu Nallapati, Min Feng Tseng, Pei Ling Chen, Shih Ching Chuang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A novel unprecedented triphenylphosphine-mediated [4 + 3] annulation reaction of 2-benzylidene indane-1,3-diones and -diynoates through initial phosphine α-addition was discovered and found to result in biologically interesting indeno[1,2-b]oxepin-4-ylidenes in up to 75% yield. The seven-membered separable Z and E isomeric oxepins were confirmed using single-crystal X-ray diffraction.

Original languageEnglish
Pages (from-to)2993-2997
Number of pages5
JournalOrganic Letters
Volume24
Issue number16
DOIs
StatePublished - 29 Apr 2022

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