@article{fbae3ab716684f7aa6b3db5d8b1dc718,
title = "Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) upregulated E-cadherin expression in HepG2 cells",
abstract = "Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), a highly inducible transcriptional coactivator regulating energy homeostasis, is down-regulated in hepatoma tissues. To dissect its role in hepato-tumorigenesis, Ingenuity{\textregistered} Pathway Analysis was applied to construct pathways affected by PGC-1α upregulation in HepG2 hepatoma cells based on our microarray data. Interestingly, migration of these cells was markedly diminished by PGC-1α overexpression in consistency with Ingenuity{\textregistered} results. Moreover, a deduced expression increase of E-cadherin was also observed in PGC-1α-overexpressing HepG2 cells. Finally, transient transfection and chromatin-immunoprecipitation assays suggested that increased histone acetylation might be responsible for PGC-1α-mediated transactivation of a minimal E-cadherin promoter.",
keywords = "E-cadherin, Hepatocellular carcinoma, Histone modification, Migration, PGC-1α, Transcription",
author = "Lee, {Hui Ju} and Yeu Su and Lui, {Wing Yiu} and Chau, {Gar Yang} and Yin, {Pen Hui} and Lee, {Hsin Chen} and Chi, {Chin Wen}",
note = "Funding Information: We thank Dr. Eric Y. Chuang, Bioinformatics and Biostatistics Core of the National Taiwan University for helping of Ingenuity {\textregistered} Pathway Analysis. The authors acknowledge the technical services provided by Microarray & Gene Expression Analysis Core Facility of the National Yang-Ming University VGH Genome Research Center. The Gene Expression Analysis Core Facility is supported by National Research Program for Genomic Medicine, National Science Council. This work was supported in part by Grant (NSC95-2320-B075-008-MY2 and NSC96-2320-B075-008- MY2) from the National Science Council, Republic of China.",
year = "2008",
month = mar,
day = "5",
doi = "10.1016/j.febslet.2008.01.033",
language = "English",
volume = "582",
pages = "627--634",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "5",
}