TY - JOUR
T1 - Patterns of fractional amplitude of low-frequency oscillations in occipito-striato-thalamic regions of first-episode drug-naïve panic disorder
AU - Lai, Chien Han
AU - Wu, Yu Te
N1 - Funding Information:
We want to thank for the Grant support from Buddhist Tzu-Chi General Hospital, Taipei Branch hospital project TCRD-TPE-99-02 . We also acknowledge MR support from National Yang-Ming University, Taiwan , which is in part supported by the MOE plan for the top university.
PY - 2012/12/15
Y1 - 2012/12/15
N2 - Objective: This study was designed to investigate patterns of fractional amplitude of low-frequency fluctuations (fALFF, an indicator for the intensity of regional brain spontaneous activities) of patients with first-episode drug-naïve panic disorder (PD). Methods: Thirty patients (17 females, 13 males, age: 47.70±10.69 years old) and twenty healthy controls (10 females, 10 males, age: 41.40±13.94 years old) received 3-Tesla resting-state functional magnetic resonance imaging (RFMRI) scanning and the rating of clinical scales. RFMRI data was processed and analyzed by the REST toolbox (resting-state functional MRI data analysis toolbox) to calculate fALFF. fALFF were compared between patients and controls to detect endophenotype of fALFF in patients with first-episode drug-naïve PD. Results: We found decreased fALFF in right middle occipital gyrus [FDR (false discovery rate) corrected p<0.05, cluster >5 voxles, volume >135 mm3, T threshold: 6.1168, surface connected theory] and increased fALFF in right putamen and right ventral lateral nucleus of thalamus of patients (uncorrected p<0.00005, cluster >5 voxles, volume >135 mm3, T threshold: 4.5439, surface connected theory). fALFF of patients also showed a positive correlation with clinical rating scores of PD in right cuneus. Conclusions: Occipito-striato-thalamic dysfunction of fALFF might represent a kind of endophenotype biomarker of first-episode drug-naïve PD.
AB - Objective: This study was designed to investigate patterns of fractional amplitude of low-frequency fluctuations (fALFF, an indicator for the intensity of regional brain spontaneous activities) of patients with first-episode drug-naïve panic disorder (PD). Methods: Thirty patients (17 females, 13 males, age: 47.70±10.69 years old) and twenty healthy controls (10 females, 10 males, age: 41.40±13.94 years old) received 3-Tesla resting-state functional magnetic resonance imaging (RFMRI) scanning and the rating of clinical scales. RFMRI data was processed and analyzed by the REST toolbox (resting-state functional MRI data analysis toolbox) to calculate fALFF. fALFF were compared between patients and controls to detect endophenotype of fALFF in patients with first-episode drug-naïve PD. Results: We found decreased fALFF in right middle occipital gyrus [FDR (false discovery rate) corrected p<0.05, cluster >5 voxles, volume >135 mm3, T threshold: 6.1168, surface connected theory] and increased fALFF in right putamen and right ventral lateral nucleus of thalamus of patients (uncorrected p<0.00005, cluster >5 voxles, volume >135 mm3, T threshold: 4.5439, surface connected theory). fALFF of patients also showed a positive correlation with clinical rating scores of PD in right cuneus. Conclusions: Occipito-striato-thalamic dysfunction of fALFF might represent a kind of endophenotype biomarker of first-episode drug-naïve PD.
KW - Fractional amplitude of low-frequency fluctuations
KW - Panic disorder
KW - Right middle occipital gyrus
KW - Right putamen
KW - Right ventral lateral nucleus of thalamus
UR - http://www.scopus.com/inward/record.url?scp=84868140976&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2012.04.021
DO - 10.1016/j.jad.2012.04.021
M3 - Article
C2 - 22770722
AN - SCOPUS:84868140976
SN - 0165-0327
VL - 142
SP - 180
EP - 185
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1-3
ER -
