This paper proposes a mobile robot navigation control design based on deep vSLAM approach. The deep vSLAM system integrates ORB-SLAM2 with a deep neural network (DNN) to enhance the localization performance of an embedded navigation system. An RGB-D camera is utilized to realize the deep vSLAM system. In the proposed deep vSLAM algorithm, the DNN works to accelerate feature matching and feature detection steps in the original ORB-SLAM2. Further, we developed a path-tracking controller to navigate the robot on the planned path based on the vSLAM localization. Several interesting experiments are presented to validate the performance of the proposed method. The experimental results on a mobile robot show that the computation time of the DNN based feature matching is reduced to 45.16% of that of the original ORB-SLAM2, and the path-tracking error of a squared-shape path of 19.8m is within 20mm.