Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application

Anna F.Y. Li, Chia Lin Wang, Hsiao Yun Tai, Yun Ju Fu, Fu Ting Tsai, Yi Ching Tsai, Yu Ling Ko, Mei Jane Li, Chiou Chyn Lin, Tai Jay Chang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy fields. Herein, we present the characteristics of Dexamethasone, from molecular mechanisms such as genomic and nongenomic pathways by cellular signal regulations, to clinical applications in various phases of the disease. During COVID-19 pandemic, Dexamethasone given to patients who required oxygen or ventilation therapy showed improved life efficacy.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalJournal of the Chinese Medical Association
Issue number3
StatePublished - Mar 2021


  • COVID-19
  • Dexamethasone
  • Molecular mechanisms


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