Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application

Anna F.Y. Li; Chia Lin Wang; Hsiao Yun Tai; Yun Ju Fu; Fu Ting Tsai; Yi Ching Tsai; Yu Ling Ko; Mei Jane Li; Chiou Chyn Lin; Tai Jay Chang

doi:10.1097/JCMA.0000000000000485

Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application

Anna F.Y. Li, Chia Lin Wang, Hsiao Yun Tai, Yun Ju Fu, Fu Ting Tsai, Yi Ching Tsai, Yu Ling Ko, Mei Jane Li, Chiou Chyn Lin, Tai Jay Chang^*

^*Corresponding author for this work

Department of Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy fields. Herein, we present the characteristics of Dexamethasone, from molecular mechanisms such as genomic and nongenomic pathways by cellular signal regulations, to clinical applications in various phases of the disease. During COVID-19 pandemic, Dexamethasone given to patients who required oxygen or ventilation therapy showed improved life efficacy.

Original language	English
Pages (from-to)	245-247
Number of pages	3
Journal	Journal of the Chinese Medical Association
Volume	84
Issue number	3
DOIs	https://doi.org/10.1097/JCMA.0000000000000485
State	Published - Mar 2021

Keywords

COVID-19
Dexamethasone
Molecular mechanisms

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10.1097/JCMA.0000000000000485

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title = "Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application",

abstract = "The rapid spread of coronavirus disease (COVID-19) in many countries has caused inconvenience in conducting daily life activities, and even deaths. Dexamethasone is a corticosteroid applied in clinical medicine since 1957, especially in immune therapy fields. Herein, we present the characteristics of Dexamethasone, from molecular mechanisms such as genomic and nongenomic pathways by cellular signal regulations, to clinical applications in various phases of the disease. During COVID-19 pandemic, Dexamethasone given to patients who required oxygen or ventilation therapy showed improved life efficacy.",

keywords = "COVID-19, Dexamethasone, Molecular mechanisms",

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note = "Publisher Copyright: Copyright {\textcopyright} 2020, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)",

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AU - Tai, Hsiao Yun

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AU - Tsai, Fu Ting

AU - Tsai, Yi Ching

AU - Ko, Yu Ling

AU - Li, Mei Jane

AU - Lin, Chiou Chyn

AU - Chang, Tai Jay

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Pandemic aspect of dexamethasone: Molecular mechanisms and clinical application

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Keywords

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