Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot

Venkatachalam Rajeshkumar; Tai Hua Lee; Shih-Ching Chuang

doi:10.1021/ol4001922

Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot

Venkatachalam Rajeshkumar, Tai Hua Lee, Shih-Ching Chuang^*

^*Corresponding author for this work

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.

Original language	English
Pages (from-to)	1468-1471
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	7
DOIs	https://doi.org/10.1021/ol4001922
State	Published - 5 Apr 2013

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10.1021/ol4001922

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title = "Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot",

abstract = "Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.",

author = "Venkatachalam Rajeshkumar and Lee, {Tai Hua} and Shih-Ching Chuang",

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doi = "10.1021/ol4001922",

language = "English",

volume = "15",

pages = "1468--1471",

journal = "Organic Letters",

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Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot. / Rajeshkumar, Venkatachalam; Lee, Tai Hua; Chuang, Shih-Ching.
In: Organic Letters, Vol. 15, No. 7, 05.04.2013, p. 1468-1471.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation

T2 - Access to bioactive phenanthridinone derivatives in one pot

AU - Rajeshkumar, Venkatachalam

AU - Lee, Tai Hua

AU - Chuang, Shih-Ching

PY - 2013/4/5

Y1 - 2013/4/5

N2 - Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.

AB - Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.

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VL - 15

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JO - Organic Letters

JF - Organic Letters

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ER -

Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot

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