Palladium-Catalyzed Direct Cross-Dehydrogenative Alkynylation of Selenophenes

Shi Yen Chen, Yan Hsiang Tseng, Chia Fang Lu, Chun Yao Chuang, Yen Ju Cheng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A palladium-catalyzed (Pd(PPh3)4/Ag2O/PivOH) C2-regioselective direct dehydrogenative alkynylation of unsubstituted selenophene was achieved. The selenophenes substituted with R1 groups at 2-position can be C5-alkynylated with a variety of 4-substituted phenylacetylenes (R2 groups). The R1 and R2 can be either electron-withdrawing or electron-donating groups, demonstrating a wide range of substrate scope with various functional group tolerance. The mono/C2-alkynylated selenophenes can subsequently undergo the second direct alkynylation at C5-position to afford symmetrical or unsymmetrical donor-π-acceptor 2,5-dialkynylated selenophenes. (Figure presented.).

Original languageEnglish
Pages (from-to)4526-4531
Number of pages6
JournalAdvanced Synthesis and Catalysis
Issue number19
StatePublished - 5 Oct 2021


  • C−H activation
  • dehydrogenative alkynylation
  • Pd-catalyzed
  • selenophene


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