Palladium-catalyzed alpha-arylation of indolin-3-ones

Yu-Hsuan Chang, Wan-Ling Peng, I. Chia Chen, Hsin-Yun Hsu, Yen-Ku Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

Original languageEnglish
Pages (from-to)4660-4663
Number of pages4
JournalChemical Communications
Issue number34
StatePublished - 30 Apr 2020




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