Palladium-catalyzed alpha-arylation of indolin-3-ones

Yu-Hsuan Chang; Wan-Ling Peng; I. Chia Chen; Hsin-Yun Hsu; Yen-Ku Wu

doi:10.1039/d0cc00435a

Palladium-catalyzed alpha-arylation of indolin-3-ones

Yu-Hsuan Chang, Wan-Ling Peng, I. Chia Chen, Hsin-Yun Hsu, Yen-Ku Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

Original language	English
Pages (from-to)	4660-4663
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	34
DOIs	https://doi.org/10.1039/d0cc00435a
State	Published - 30 Apr 2020

Keywords

OXINDOLES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d0cc00435a

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abstract = "A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.",

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AU - Chang, Yu-Hsuan

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AU - Chen, I. Chia

AU - Hsu, Hsin-Yun

AU - Wu, Yen-Ku

PY - 2020/4/30

Y1 - 2020/4/30

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AB - A method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.

KW - OXINDOLES

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DO - 10.1039/d0cc00435a

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EP - 4663

JO - Chemical Communications

JF - Chemical Communications

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ER -

Palladium-catalyzed alpha-arylation of indolin-3-ones

Abstract

Keywords

UN SDGs

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