Optical waveguide biosensors constructed with subwavelength gratings

Jenq Nan Yih; Yi Ming Chu; Yen Chieh Mao; Wei Han Wang; Fan Ching Chien; Chun Yu Lin; Kuang Li Lee; Pei Kuen Wei; Shean Jen Chen

doi:10.1364/AO.45.001938

Optical waveguide biosensors constructed with subwavelength gratings

Jenq Nan Yih^*, Yi Ming Chu, Yen Chieh Mao, Wei Han Wang, Fan Ching Chien, Chun Yu Lin, Kuang Li Lee, Pei Kuen Wei, Shean Jen Chen

^*Corresponding author for this work

Institute of Imaging and Biomedical Photonics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The reflection resonance spectrum of a subwavelength diffraction-grating- coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this resonance wavelength shift, the optical waveguide biosensor provides the ability to identify the kinetics of the biomolecular interaction on an on-line basis without the need for extrinsic labeling of the biomolecules. A theoretical analysis of the subwavelength optical waveguide biosensor is performed. A biosensor with a narrow reflection resonance spectrum, and hence an enhanced detection resolution, is then designed and fabricated. Currently, the detection limit of the optical waveguide sensor is approximately 10^-5refractive-index units. The biosensor is successfully applied to study of the dynamic response of an antibody interaction with protein G adsorbed on the sensing surface.

Original language	English
Pages (from-to)	1938-1942
Number of pages	5
Journal	Applied Optics
Volume	45
Issue number	9
DOIs	https://doi.org/10.1364/AO.45.001938
State	Published - 20 Mar 2006

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title = "Optical waveguide biosensors constructed with subwavelength gratings",

abstract = "The reflection resonance spectrum of a subwavelength diffraction-grating- coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this resonance wavelength shift, the optical waveguide biosensor provides the ability to identify the kinetics of the biomolecular interaction on an on-line basis without the need for extrinsic labeling of the biomolecules. A theoretical analysis of the subwavelength optical waveguide biosensor is performed. A biosensor with a narrow reflection resonance spectrum, and hence an enhanced detection resolution, is then designed and fabricated. Currently, the detection limit of the optical waveguide sensor is approximately 10-5refractive-index units. The biosensor is successfully applied to study of the dynamic response of an antibody interaction with protein G adsorbed on the sensing surface.",

author = "Yih, {Jenq Nan} and Chu, {Yi Ming} and Mao, {Yen Chieh} and Wang, {Wei Han} and Chien, {Fan Ching} and Lin, {Chun Yu} and Lee, {Kuang Li} and Wei, {Pei Kuen} and Chen, {Shean Jen}",

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T1 - Optical waveguide biosensors constructed with subwavelength gratings

AU - Yih, Jenq Nan

AU - Chu, Yi Ming

AU - Mao, Yen Chieh

AU - Wang, Wei Han

AU - Chien, Fan Ching

AU - Lin, Chun Yu

AU - Lee, Kuang Li

AU - Wei, Pei Kuen

AU - Chen, Shean Jen

PY - 2006/3/20

Y1 - 2006/3/20

N2 - The reflection resonance spectrum of a subwavelength diffraction-grating- coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this resonance wavelength shift, the optical waveguide biosensor provides the ability to identify the kinetics of the biomolecular interaction on an on-line basis without the need for extrinsic labeling of the biomolecules. A theoretical analysis of the subwavelength optical waveguide biosensor is performed. A biosensor with a narrow reflection resonance spectrum, and hence an enhanced detection resolution, is then designed and fabricated. Currently, the detection limit of the optical waveguide sensor is approximately 10-5refractive-index units. The biosensor is successfully applied to study of the dynamic response of an antibody interaction with protein G adsorbed on the sensing surface.

AB - The reflection resonance spectrum of a subwavelength diffraction-grating- coupled waveguide is used to analyze biomolecular interactions in real time. By detecting this resonance wavelength shift, the optical waveguide biosensor provides the ability to identify the kinetics of the biomolecular interaction on an on-line basis without the need for extrinsic labeling of the biomolecules. A theoretical analysis of the subwavelength optical waveguide biosensor is performed. A biosensor with a narrow reflection resonance spectrum, and hence an enhanced detection resolution, is then designed and fabricated. Currently, the detection limit of the optical waveguide sensor is approximately 10-5refractive-index units. The biosensor is successfully applied to study of the dynamic response of an antibody interaction with protein G adsorbed on the sensing surface.

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DO - 10.1364/AO.45.001938

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SN - 1559-128X

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Optical waveguide biosensors constructed with subwavelength gratings

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