Optical biosensor based on localized surface plasmon resonance with high spatial resolution

Xin Hong*, Fu Jen Kao

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

We are using a gold nanoparticle coated film to achieve high spatially resolved biosensing that is based on localized surface plasmon resonance (LSPR). This special film possesses the unique optical properties of being not sensitive to the changes of incident angle and relies exclusively on the spectral shift of absorption peak for biosensing. This uniqueness enables it to be compatible with high numerical aperture (NA) optics and to achieve high spatial resolution. We demonstrate a spatial resolution of 25μm assuming a maximum of spectral fluctuation of 0.1nm is acceptable.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5327
DOIs
StatePublished - 2004
EventPlasmonics in Biology and Medicine - San Jose, CA, United States
Duration: 26 Jan 200427 Jan 2004

Keywords

  • Bio-interaction
  • Biosensor
  • Gold nanoparticle film
  • Microscopy
  • Numerical aperture
  • Spatial resolution
  • Surface plasmon resonance

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