Oligonucleotides as 'bio-solvent' for in situ extraction and functionalisation of carbon nanoparticles

Yu Cheng Chen, Cheng Che Wen, Ian Liau, You-Zung Hsieh, Hsin-Yun Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A simple yet novel one-pot approach is developed to prepare carbon nanoparticles with diameters of ∼2 nm and modified by oligonucleotides. We use single-stranded deoxyribonucleic acid (ssDNA), which serves as a unique 'bio-solvent' for carbon nanoparticle (CNP) preparation and as a target molecule for functionalisation. Proposed interactions relevant to the stabilisation of the final oligonucleotide-CNP complex include π-π stacking and π-HN bonding with sp2 carbon atoms on the CNP surface. Furthermore, oligonucleotide-enriched CNPs can be readily extracted within seconds from a crude mixture of single-walled carbon nanotubes (SWCNTs) without any need for post-synthesis chemical modification. The established CNPs are biocompatible, possess intrinsic fluorescence, and do not result in the undesirable photobleaching effect, rendering them potential candidates for in vivo biological applications.

Original languageEnglish
Pages (from-to)4100-4107
Number of pages8
JournalJournal of Materials Chemistry B
Issue number26
StatePublished - 23 Apr 2014


Dive into the research topics of 'Oligonucleotides as 'bio-solvent' for in situ extraction and functionalisation of carbon nanoparticles'. Together they form a unique fingerprint.

Cite this