Novel Therapeutic Targets Against Spreading Depression

Shih Pin Chen, Cenk Ayata*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Migraine is among the most prevalent and disabling neurological diseases in the world. Cortical spreading depression (SD) is an intense wave of neuronal and glial depolarization underlying migraine aura, and a headache trigger, which has been used as an experimental platform for drug screening in migraine. Here, we provide an overview of novel therapeutic targets that show promise to suppress SD, such as acid-sensing ion channels, casein kinase Iδ, P2X7-pannexin 1 complex, and neuromodulation, and outline the experimental models and essential quality measures for rigorous and reproducible efficacy testing.

Original languageEnglish
Pages (from-to)1340-1358
Number of pages19
Issue number9
StatePublished - Oct 2017


  • aura
  • cortical spreading depression
  • ion channels
  • migraine
  • neuromodulation
  • susceptibility


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